DNAJC3
DnaJ homolog subfamily C member 3
Also known as: DNJC3_HUMAN, ERdj6, HP58, P58, p58(IPK), P58IPK, PRKRI
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q13217
- Gene
- DNAJC3
- Ensembl
- ENSG00000102580
- Chromosome
- 13
- Canonical length
- 504 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted intracellular proteins
- Subcellular location
- Endoplasmic reticulum
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Canonical amino-acid sequenceUniProt
504 residues, UniProt reviewed canonical sequence.
>Q13217|DNAJC3
1 MVAPGSVTSR LGSVFPFLLV LVDLQYEGAE CGVNADVEKH LELGKKLLAA GQLADALSQF
61 HAAVDGDPDN YIAYYRRATV FLAMGKSKAA LPDLTKVIQL KMDFTAARLQ RGHLLLKQGK
121 LDEAEDDFKK VLKSNPSENE EKEAQSQLIK SDEMQRLRSQ ALNAFGSGDY TAAIAFLDKI
181 LEVCVWDAEL RELRAECFIK EGEPRKAISD LKAASKLKND NTEAFYKIST LYYQLGDHEL
241 SLSEVRECLK LDQDHKRCFA HYKQVKKLNK LIESAEELIR DGRYTDATSK YESVMKTEPS
301 IAEYTVRSKE RICHCFSKDE KPVEAIRVCS EVLQMEPDNV NALKDRAEAY LIEEMYDEAI
361 QDYETAQEHN ENDQQIREGL EKAQRLLKQS QKRDYYKILG VKRNAKKQEI IKAYRKLALQ
421 WHPDNFQNEE EKKKAEKKFI DIAAAKEVLS DPEMRKKFDD GEDPLDAESQ QGGGGNPFHR
481 SWNSWQGFNP FSSGGPFRFK FHFNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DNAJC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 49 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 49 nTPM
- bone marrow: 43 nTPM
- liver: 39 nTPM
- epididymis: 37 nTPM
- salivary gland: 34 nTPM
- pancreas: 34 nTPM
Single-cell type
- neutrophils: 695 nCPM
- neutrophil progenitors: 458 nCPM
- plasma cells: 449 nCPM
- epididymal principal cells: 360 nCPM
- syncytiotrophoblasts: 305 nCPM
- lacrimal acinar cells: 298 nCPM
Immune cell
- eosinophil: 86 nTPM
- neutrophil: 77 nTPM
- basophil: 65 nTPM
- plasmacytoid DC: 46 nTPM
- non-classical monocyte: 36 nTPM
- intermediate monocyte: 32 nTPM
Brain region
- choroid plexus: 47 nTPM
- white matter: 33 nTPM
- medulla oblongata: 33 nTPM
- thalamus: 32 nTPM
- hypothalamus: 30 nTPM
- spinal cord: 29 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about DNAJC3.
Disease | AllUniProt
Conditions DNAJC3 is implicated in, by any mechanism.
- Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus (ACPHD) MIM:616192
Disease | GeneticClinVar
9 pathogenic / likely-pathogenic of 90 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.52
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 1.71
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to cold
- defense response to virus
- negative regulation of apoptotic process
- negative regulation of translation in response to endoplasmic reticulum stress
- protein folding in endoplasmic reticulum
- proteolysis involved in protein catabolic process
- response to unfolded protein
- negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
- positive regulation of translation initiation in response to endoplasmic reticulum stress
Molecular functions
- misfolded protein binding
- protein kinase binding
- protein kinase inhibitor activity
- protein-folding chaperone binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DNAJC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DNAJC3 as an antibody target. Whether an autoantibody or antibody against DNAJC3 could matter depends on whether native DNAJC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DNAJC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DNAJC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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