Seroatlas · Human Serome Atlas

ZNF526

Zinc finger protein 526

Also known as: KIAA1951, MGC4267, ZN526_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF50
Gene: ZNF526
Ensembl: ENSG00000167625
Chromosome: 19
Canonical length: 670 aa
Protein class: Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>Q8TF50|ZNF526
     1  MAEVVAEVAE MPTQMSPGAV EMSTPMSAEM MEMSTEVTEM TPGEALASSL FFQHHQFMCS
    61  ECGSLYNTLE EVLSHQEQHM LAVSEEEALT TQNVGLEPEL VPGAEGPFQC GECSQLILSP
   121  GELLAHQDAH LRESANQIQY QCWDCQELFP SPELWVAHRK AQHLSATVAE PPVPPPLPPP
   181  TPLPPPSPPS EVKMEPYECP ECSTLCATPE EFLEHQGTHF DSLEKEERNG LEEEEEDDEE
   241  DEEDDEEMED EEAMAEVGDD AVGGDESTAG WAQGCGDCPQ HQPSAGARRQ HRRTAHSPAS
   301  ATHPFHCSQC QRSFSSANRL QAHGRAHVGG THECTTCSKV FKKAASLEQH LRLHRGEARY
   361  LCVDCGRGFG TELTLVAHRR AHTANPLHRC RCGKTFSNMT KFLYHRRTHA GKSGAPPTGA
   421  TAPPAPAEPT PPPPPPAPPA QLPCPQCSKS FASASRLSRH RRAVHGPPER RHRCGVCGKG
   481  FKKLIHVRNH LRTHTGERPF QCHSCGKTFA SLANLSRHQL THTGARPYQC LDCGKRFTQS
   541  SNLQQHRRLH LRPVAFARAP RLPITGLYNK SPYYCGTCGR WFRAMAGLRL HQRVHARART
   601  LTLQPPRSPS PAPPPPPEPQ QTIMCTELGE TIAIIETSQP LALEDTLQLC QAALGASEAG
   661  GLLQLDTAFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF526 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

skin: 4.9 nTPM
skeletal muscle: 4.7 nTPM
salivary gland: 4.3 nTPM
thymus: 3.9 nTPM
endometrium: 3.8 nTPM
lymph node: 3.8 nTPM

Single-cell type

erythrocyte progenitors: 13 nCPM
cone photoreceptor cells: 12 nCPM
retinal ganglion cells: 12 nCPM
syncytiotrophoblasts: 12 nCPM
colonocytes: 11 nCPM
differentiating spermatogonia: 11 nCPM

Immune cell

MAIT T-cell: 6.9 nTPM
non-classical monocyte: 5.4 nTPM
naive CD8 T-cell: 5.3 nTPM
memory B-cell: 4.7 nTPM
gdT-cell: 4.5 nTPM
naive B-cell: 4.4 nTPM

Brain region

cerebellum: 12 nTPM
white matter: 9.6 nTPM
cerebral cortex: 7.9 nTPM
medulla oblongata: 7.9 nTPM
thalamus: 7.8 nTPM
pons: 7.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF526.

Disease | AllUniProt

Conditions ZNF526 is implicated in, by any mechanism.

Dentici-Novelli neurodevelopmental syndrome (DENNED) MIM:619877

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 152 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Dentici-Novelli neurodevelopmental syndrome
Pulmonic stenosis
Noonan-like facies
Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.52
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF526 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF526 as an antibody target. Whether an autoantibody or antibody against ZNF526 could matter depends on whether native ZNF526 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF526 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF526 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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