Seroatlas · Human Serome Atlas

CITED4

Cbp/p300-interacting transactivator 4

Also known as: CITE4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RK1
Gene
CITED4
Ensembl
ENSG00000179862
Chromosome
1
Canonical length
184 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q96RK1|CITED4
     1  MADHLMLAEG YRLVQRPPSA AAAHGPHALR TLPPYAGPGL DSGLRPRGAP LGPPPPRQPG
    61  ALAYGAFGPP SSFQPFPAVP PPAAGIAHLQ PVATPYPGRA AAPPNAPGGP PGPQPAPSAA
   121  APPPPAHALG GMDAELIDEE ALTSLELELG LHRVRELPEL FLGQSEFDCF SDLGSAPPAG
   181  SVSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CITED4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • skin: 50 nTPM
  • pancreas: 47 nTPM
  • liver: 39 nTPM
  • salivary gland: 33 nTPM
  • skeletal muscle: 31 nTPM
  • breast: 29 nTPM

Single-cell type

  • pancreatic duct cells: 462 nCPM
  • breast secretory cells: 350 nCPM
  • endometrial ciliated cells: 346 nCPM
  • cholangiocytes: 322 nCPM
  • epididymal efferent duct absorptive cells: 265 nCPM
  • retinal pigment epithelial cells: 239 nCPM

Immune cell

  • neutrophil: 0.4 nTPM
  • myeloid DC: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • midbrain: 31 nTPM
  • hypothalamus: 29 nTPM
  • medulla oblongata: 29 nTPM
  • spinal cord: 24 nTPM
  • thalamus: 24 nTPM
  • pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0.35
gnomAD missense Z
0.98
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CITED4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CITED4 as an antibody target. Whether an autoantibody or antibody against CITED4 could matter depends on whether native CITED4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CITED4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CITED4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CITED4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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