MVP

Protein identityUniProt · HPA

UniProt accession

Q14764

Gene

MVP

Ensembl

ENSG00000013364

Chromosome

16

Canonical length

893 aa

Protein class

Cancer-related genes, Predicted intracellular proteins, Transporters

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

893 residues, UniProt reviewed canonical sequence.

>Q14764|MVP
     1  MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM VTVPPRHYCT
    61  VANPVSRDAQ GLVLFDVTGQ VRLRHADLEI RLAQDPFPLY PGEVLEKDIT PLQVVLPNTA
   121  LHLKALLDFE DKDGDKVVAG DEWLFEGPGT YIPRKEVEVV EIIQATIIRQ NQALRLRARK
   181  ECWDRDGKER VTGEEWLVTT VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ARRNFRDFRG
   241  VSRRTGEEWL VTVQDTEAHV PDVHEEVLGV VPITTLGPHN YCVILDPVGP DGKNQLGQKR
   301  VVKGEKSFFL QPGEQLEQGI QDVYVLSEQQ GLLLRALQPL EEGEDEEKVS HQAGDHWLIR
   361  GPLEYVPSAK VEVVEERQAI PLDENEGIYV QDVKTGKVRA VIGSTYMLTQ DEVLWEKELP
   421  PGVEELLNKG QDPLADRGEK DTAKSLQPLA PRNKTRVVSY RVPHNAAVQV YDYREKRARV
   481  VFGPELVSLG PEEQFTVLSL SAGRPKRPHA RRALCLLLGP DFFTDVITIE TADHARLQLQ
   541  LAYNWHFEVN DRKDPQETAK LFSVPDFVGD ACKAIASRVR GAVASVTFDD FHKNSARIIR
   601  TAVFGFETSE AKGPDGMALP RPRDQAVFPQ NGLVVSSVDV QSVEPVDQRT RDALQRSVQL
   661  AIEITTNSQE AAAKHEAQRL EQEARGRLER QKILDQSEAE KARKELLELE ALSMAVESTG
   721  TAKAEAESRA EAARIEGEGS VLQAKLKAQA LAIETEAELQ RVQKVRELEL VYARAQLELE
   781  VSKAQQLAEV EVKKFKQMTE AIGPSTIRDL AVAGPEMQVK LLQSLGLKST LITDGSTPIN
   841  LFNTAFGLLG MGPEGQPLGR RVASGPSPGE GISPQSAQAP QAPGDNHVVP VLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MVP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

176 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for MVP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.73

gnomAD pLI

0

gnomAD missense Z

2.02

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell population proliferation
• ERBB signaling pathway
• intracellular signal transduction
• mRNA transport
• negative regulation of epidermal growth factor receptor signaling pathway
• protein transport
• protein activation cascade

Molecular functions

• identical protein binding
• protein kinase binding
• protein phosphatase binding

Cellular components

• cytoplasm
• cytoskeleton
• cytosol
• extracellular exosome
• extracellular region
• ficolin-1-rich granule lumen
• membrane
• nuclear pore
• nucleus
• perinuclear region of cytoplasm
• ribonucleoprotein complex
• secretory granule lumen

Protein domainsUniProt · Pfam · InterPro

• Band 7/SPFH domain superfamily
• Major vault protein, N-terminal
• Major vault protein, shoulder domain
• Major vault protein
• Major vault protein repeat domain 3
• Major vault protein repeat domain 2
• Major vault protein repeat domain 4
• Major vault protein repeat domain
• Major vault protein repeat domain superfamily
• Major vault protein repeat domain 2 superfamily
• Major Vault Protein repeat domain
• Shoulder domain
• Major Vault Protein repeat domain
• Major Vault Protein Repeat domain
• Major Vault Protein repeat domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Isopeptide bond
• mRNA transport
• Nuclear pore complex
• Nucleus
• Phosphoprotein
• Protein transport
• Repeat
• Ribonucleoprotein
• Translocation
• Transport
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of MVP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APEX1
• PTEN
• SRC
• TEP1