PARP4

Protein identityUniProt · HPA

UniProt accession

Q9UKK3

Gene

PARP4

Ensembl

ENSG00000102699

Chromosome

13

Canonical length

1724 aa

Protein class

Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1724 residues, UniProt reviewed canonical sequence.

>Q9UKK3|PARP4
     1  MVMGIFANCI FCLKVKYLPQ QQKKKLQTDI KENGGKFSFS LNPQCTHIIL DNADVLSQYQ
    61  LNSIQKNHVH IANPDFIWKS IREKRLLDVK NYDPYKPLDI TPPPDQKASS SEVKTEGLCP
   121  DSATEEEDTV ELTEFGMQNV EIPHLPQDFE VAKYNTLEKV GMEGGQEAVV VELQCSRDSR
   181  DCPFLISSHF LLDDGMETRR QFAIKKTSED ASEYFENYIE ELKKQGFLLR EHFTPEATQL
   241  ASEQLQALLL EEVMNSSTLS QEVSDLVEMI WAEALGHLEH MLLKPVNRIS LNDVSKAEGI
   301  LLLVKAALKN GETAEQLQKM MTEFYRLIPH KGTMPKEVNL GLLAKKADLC QLIRDMVNVC
   361  ETNLSKPNPP SLAKYRALRC KIEHVEQNTE EFLRVRKEVL QNHHSKSPVD VLQIFRVGRV
   421  NETTEFLSKL GNVRPLLHGS PVQNIVGILC RGLLLPKVVE DRGVQRTDVG NLGSGIYFSD
   481  SLSTSIKYSH PGETDGTRLL LICDVALGKC MDLHEKDFSL TEAPPGYDSV HGVSQTASVT
   541  TDFEDDEFVV YKTNQVKMKY IIKFSMPGDQ IKDFHPSDHT ELEEYRPEFS NFSKVEDYQL
   601  PDAKTSSSTK AGLQDASGNL VPLEDVHIKG RIIDTVAQVI VFQTYTNKSH VPIEAKYIFP
   661  LDDKAAVCGF EAFINGKHIV GEIKEKEEAQ QEYLEAVTQG HGAYLMSQDA PDVFTVSVGN
   721  LPPKAKVLIK ITYITELSIL GTVGVFFMPA TVAPWQQDKA LNENLQDTVE KICIKEIGTK
   781  QSFSLTMSIE MPYVIEFIFS DTHELKQKRT DCKAVISTME GSSLDSSGFS LHIGLSAAYL
   841  PRMWVEKHPE KESEACMLVF QPDLDVDLPD LASESEVIIC LDCSSSMEGV TFLQAKQIAL
   901  HALSLVGEKQ KVNIIQFGTG YKELFSYPKH ITSNTMAAEF IMSATPTMGN TDFWKTLRYL
   961  SLLYPARGSR NILLVSDGHL QDESLTLQLV KRSRPHTRLF ACGIGSTANR HVLRILSQCG
  1021  AGVFEYFNAK SKHSWRKQIE DQMTRLCSPS CHSVSVKWQQ LNPDVPEALQ APAQVPSLFL
  1081  NDRLLVYGFI PHCTQATLCA LIQEKEFRTM VSTTELQKTT GTMIHKLAAR ALIRDYEDGI
  1141  LHENETSHEM KKQTLKSLII KLSKENSLIT QFTSFVAVEK RDENESPFPD IPKVSELIAK
  1201  EDVDFLPYMS WQGEPQEAVR NQSLLASSEW PELRLSKRKH RKIPFSKRKM ELSQPEVSED
  1261  FEEDGLGVLP AFTSNLERGG VEKLLDLSWT ESCKPTATEP LFKKVSPWET STSSFFPILA
  1321  PAVGSYLPPT ARAHSPASLS FASYRQVASF GSAAPPRQFD ASQFSQGPVP GTCADWIPQS
  1381  ASCPTGPPQN PPSSPYCGIV FSGSSLSSAQ SAPLQHPGGF TTRPSAGTFP ELDSPQLHFS
  1441  LPTDPDPIRG FGSYHPSASS PFHFQPSAAS LTANLRLPMA SALPEALCSQ SRTTPVDLCL
  1501  LEESVGSLEG SRCPVFAFQS SDTESDELSE VLQDSCFLQI KCDTKDDSIL CFLEVKEEDE
  1561  IVCIQHWQDA VPWTELLSLQ TEDGFWKLTP ELGLILNLNT NGLHSFLKQK GIQSLGVKGR
  1621  ECLLDLIATM LVLQFIRTRL EKEGIVFKSL MKMDDASISR NIPWAFEAIK QASEWVRRTE
  1681  GQYPSICPRL ELGNDWDSAT KQLLGLQPIS TVSPLHRVLH YSQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

37 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.84

gnomAD pLI

0

gnomAD missense Z

0.13

DepMap mean gene effect

0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA damage response
• DNA repair
• inflammatory response
• protein modification process
• response to xenobiotic stimulus

Molecular functions

• DNA binding
• enzyme binding
• NAD+ poly-ADP-ribosyltransferase activity
• NAD+-protein mono-ADP-ribosyltransferase activity
• NAD+-protein-aspartate ADP-ribosyltransferase activity
• NAD+-protein-glutamate ADP-ribosyltransferase activity
• nucleotidyltransferase activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• membrane
• nucleoplasm
• nucleus
• ribonucleoprotein complex
• spindle microtubule

Protein domainsUniProt · Pfam · InterPro

• BRCT domain
• von Willebrand factor, type A
• Poly(ADP-ribose) polymerase, regulatory domain
• Poly(ADP-ribose) polymerase, catalytic domain
• VIT domain
• BRCT domain superfamily
• von Willebrand factor A-like domain superfamily
• Poly(ADP-ribose) polymerase, regulatory domain superfamily
• von Willebrand factor type A domain
• BRCA1 C Terminus (BRCT) domain
• Poly(ADP-ribose) polymerase catalytic domain
• Vault protein inter-alpha-trypsin domain
• Protein mono-ADP-ribosyltransferase PARP4
• PARP4, MVP-ID C-terminal domain
• PARP4, WGR-like domain
• PARP4 MVP-ID C-terminal domain
• PARP4 WGR-like domain

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• Glycosyltransferase
• Methylation
• NAD
• Nucleotidyltransferase
• Nucleus
• Phosphoprotein
• Ribonucleoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PARP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TEP1