Seroatlas · Human Serome Atlas

AGTRAP

Type-1 angiotensin II receptor-associated protein

Also known as: ATRAP, ATRAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6RW13
Gene: AGTRAP
Ensembl: ENSG00000177674
Chromosome: 1
Canonical length: 159 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q6RW13|AGTRAP
     1  MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS IDAISMFLGG
    61  LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP LSCCFVYHMY RERGGELLVH
   121  TGFLGSSQDR SAYQTIDSAE APADPFAVPE GRSQDARGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGTRAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 125 nTPM
choroid plexus: 115 nTPM
spleen: 80 nTPM
prostate: 75 nTPM
pancreas: 63 nTPM
kidney: 62 nTPM

Single-cell type

neutrophils: 320 nCPM
epididymal principal cells: 242 nCPM
monocytes: 156 nCPM
pancreatic acinar cells: 152 nCPM
monocyte progenitors: 148 nCPM
neutrophil progenitors: 136 nCPM

Immune cell

classical monocyte: 846 nTPM
neutrophil: 760 nTPM
eosinophil: 696 nTPM
total PBMC: 577 nTPM
basophil: 486 nTPM
intermediate monocyte: 443 nTPM

Brain region

choroid plexus: 58 nTPM
medulla oblongata: 45 nTPM
thalamus: 34 nTPM
white matter: 31 nTPM
hypothalamus: 31 nTPM
pons: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.19
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Type-1 angiotensin II receptor-associated protein
Angiotensin II, type I receptor-associated protein (AGTRAP)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGTRAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGTRAP as an antibody target. Whether an autoantibody or antibody against AGTRAP could matter depends on whether native AGTRAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGTRAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGTRAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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