Seroatlas · Human Serome Atlas

SNAPC1

snRNA-activating protein complex subunit 1

Also known as: PTFgamma, SNAP43, SNPC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16533
Gene: SNAPC1
Ensembl: ENSG00000023608
Chromosome: 14
Canonical length: 368 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q16533|SNAPC1
     1  MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA
    61  LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF
   121  DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM
   181  LNVHDHYQNM KHVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN
   241  DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ
   301  VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE NESLSGTEFT
   361  ASKKRRKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAPC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
cervix: 9.5 nTPM
urinary bladder: 9.3 nTPM
adrenal gland: 8.5 nTPM
placenta: 8.2 nTPM
heart muscle: 7.7 nTPM

Single-cell type

late primary spermatocytes: 150 nCPM
early primary spermatocytes: 140 nCPM
endometrial ciliated cells: 110 nCPM
endometrial glandular cells: 108 nCPM
epididymal basal cells: 105 nCPM
renal collecting duct principal cells: 100 nCPM

Immune cell

naive B-cell: 8.8 nTPM
naive CD4 T-cell: 8.8 nTPM
memory B-cell: 8.4 nTPM
basophil: 7.7 nTPM
NK-cell: 7.1 nTPM
plasmacytoid DC: 6.8 nTPM

Brain region

midbrain: 18 nTPM
cerebellum: 15 nTPM
medulla oblongata: 15 nTPM
white matter: 15 nTPM
choroid plexus: 14 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: -1.62
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

snRNA-activating protein complex subunit 1
Small nuclear RNA activating complex (SNAPc), subunit 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNAPC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNAPC1 as an antibody target. Whether an autoantibody or antibody against SNAPC1 could matter depends on whether native SNAPC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNAPC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNAPC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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