Seroatlas · Human Serome Atlas

SNAPC2

snRNA-activating protein complex subunit 2

Also known as: PTFdelta, SNAP45, SNPC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13487
Gene: SNAPC2
Ensembl: ENSG00000104976
Chromosome: 19
Canonical length: 334 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q13487|SNAPC2
     1  MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA
    61  EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV
   121  AFSQVLTIAA TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR
   181  TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL
   241  PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE
   301  HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAPC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

endometrium: 51 nTPM
cervix: 38 nTPM
blood vessel: 37 nTPM
fallopian tube: 36 nTPM
colon: 35 nTPM
testis: 32 nTPM

Single-cell type

decidual stromal cells: 87 nCPM
oocytes: 65 nCPM
undifferentiated spermatogonia: 48 nCPM
smooth muscle cells: 47 nCPM
breast secretory cells: 38 nCPM
megakaryocytes: 37 nCPM

Immune cell

non-classical monocyte: 34 nTPM
intermediate monocyte: 31 nTPM
myeloid DC: 30 nTPM
NK-cell: 28 nTPM
T-reg: 24 nTPM
classical monocyte: 24 nTPM

Brain region

cerebral cortex: 30 nTPM
basal ganglia: 22 nTPM
hippocampal formation: 21 nTPM
pons: 20 nTPM
hypothalamus: 19 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.1
gnomAD missense Z: -1.46
DepMap mean gene effect: -1.29
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA polymerase II general transcription initiation factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small nuclear RNA activating complex subunit 2
Small nuclear RNA activating complex (SNAPc), subunit 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNAPC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNAPC2 as an antibody target. Whether an autoantibody or antibody against SNAPC2 could matter depends on whether native SNAPC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNAPC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNAPC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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