SNAPC3

Protein identityUniProt · HPA

UniProt accession

Q92966

Gene

SNAPC3

Ensembl

ENSG00000164975

Chromosome

9

Canonical length

411 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Nuclear bodies

OverviewNCBI Gene

Predicted to enable RNA polymerase III type 3 promoter sequence-specific DNA binding activity and bent DNA binding activity. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and core promoter sequence-specific DNA binding activity. Predicted to be involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Located in nuclear body and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q92966|SNAPC3
     1  MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL WRGRLRGAGD
    61  LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL RAVCGLDKLK CLEDGEDPEV
   121  IPENTDLVTL GVRKRFLEHR EETITIDRAC RQETFVYEME SHAIGKKPEN SADMIEEGEL
   181  ILSVNILYPV IFHKHKEHKP YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE
   241  HISKDLYKSA FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND
   301  LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW TRKCFVCKMY
   361  TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL AYPYVDPGTF N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAPC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.02

gnomAD pLI

0

gnomAD missense Z

-1.03

DepMap mean gene effect

-1.27

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• snRNA transcription
• snRNA transcription by RNA polymerase II
• snRNA transcription by RNA polymerase III
• transcription by RNA polymerase II
• transcription by RNA polymerase III

Molecular functions

• bent DNA binding
• DNA binding
• RNA polymerase III general transcription initiation factor activity
• RNA polymerase III type 3 promoter sequence-specific DNA binding

Cellular components

• nuclear body
• nucleolus
• nucleoplasm
• nucleus
• snRNA-activating protein complex

Protein domainsUniProt · Pfam · InterPro

• snRNA-activating protein complex, subunit 3
• snRNA-activating protein complex (SNAPc), subunit 3

KeywordsUniProt

• DNA-binding
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of SNAPC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SNAPC1