Seroatlas · Human Serome Atlas

SNAPC5

snRNA-activating protein complex subunit 5

Also known as: SNAP19, SNPC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75971
Gene: SNAPC5
Ensembl: ENSG00000174446
Chromosome: 15
Canonical length: 98 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>O75971|SNAPC5
     1  MLSRLQELRK EEETLLRLKA ALHDQLNRLK VEELALQSMI SSRRGDEMLS SHTVPEQSHD
    61  MLVHVDNEAS INQTTLELST KSHVTEEEEE EEEEESDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAPC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 43 nTPM
skeletal muscle: 41 nTPM
epididymis: 39 nTPM
amygdala: 37 nTPM
cerebral cortex: 36 nTPM
heart muscle: 36 nTPM

Single-cell type

late primary spermatocytes: 143 nCPM
late spermatids: 129 nCPM
early spermatids: 116 nCPM
epididymal principal cells: 84 nCPM
early primary spermatocytes: 80 nCPM
hofbauer cells: 72 nCPM

Immune cell

naive CD4 T-cell: 54 nTPM
T-reg: 51 nTPM
NK-cell: 49 nTPM
non-classical monocyte: 47 nTPM
naive CD8 T-cell: 45 nTPM
memory CD8 T-cell: 45 nTPM

Brain region

choroid plexus: 29 nTPM
hypothalamus: 27 nTPM
midbrain: 26 nTPM
white matter: 25 nTPM
cerebellum: 25 nTPM
pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -0.72
DepMap mean gene effect: -1.22
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

snRNA-activating protein complex subunit 5
snRNA-activating protein complex subunit 19, SNAPc subunit 19

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNAPC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNAPC5 as an antibody target. Whether an autoantibody or antibody against SNAPC5 could matter depends on whether native SNAPC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNAPC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNAPC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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