Seroatlas · Human Serome Atlas

SLURP2

Secreted Ly-6/uPAR domain-containing protein 2

Also known as: SLUR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DP57
Gene: SLURP2
Ensembl: ENSG00000283992
Chromosome: 8
Canonical length: 97 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a novel, secreted member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This gene is mainly expressed in epithelial cells, including skin and keratinocytes, and is up-regulated in psoriatic skin lesions, suggesting its involvement in the pathophysiology of psoriasis. Alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (LYNX1) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>P0DP57|SLURP2
     1  MQLGTGLLLA AVLSLQLAAA EAIWCHQCTG FGGCSHGSRC LRDSTHCVTT ATRVLSNTED
    61  LPLVTKMCHI GCPDIPSLGL GPYVSIACCQ TSLCNHD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLURP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 867 nTPM

Expression across tissuesHPA

Tissue

esophagus: 867 nTPM
skin: 332 nTPM
vagina: 217 nTPM
cervix: 197 nTPM
salivary gland: 70 nTPM
tonsil: 22 nTPM

Single-cell type

esophageal apical cells: 39 nCPM
suprabasal keratinocytes: 6.6 nCPM
esophageal suprabasal cells: 3.7 nCPM
endometrial secretory cells: 2.3 nCPM
gastric chief cells: 1.1 nCPM
brain excitatory neurons: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 6.8 nTPM
pons: 4.4 nTPM
cerebral cortex: 3.5 nTPM
medulla oblongata: 3 nTPM
hippocampal formation: 2.8 nTPM
white matter: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.01
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLURP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLURP2 as an antibody target. Whether an autoantibody or antibody against SLURP2 could matter depends on whether native SLURP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLURP2 is annotated as secreted, so native SLURP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SLURP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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