Seroatlas · Human Serome Atlas

CHRNB4

Neuronal acetylcholine receptor subunit beta-4

Also known as: ACHB4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30926
Gene
CHRNB4
Ensembl
ENSG00000117971
Chromosome
15
Canonical length
498 aa
Protein class
FDA approved drug targets, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Cell Junctions

OverviewNCBI Gene

This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>P30926|CHRNB4
     1  MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS SQLISIKLQL
    61  SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV NILRIPAKRI WLPDIVLYNN
   121  ADGTYEVSVY TNLIVRSNGS VLWLPPAIYK SACKIEVKYF PFDQQNCTLK FRSWTYDHTE
   181  IDMVLMTPTA SMDDFTPSGE WDIVALPGRR TVNPQDPSYV DVTYDFIIKR KPLFYTINLI
   241  IPCVLTTLLA ILVFYLPSDC GEKMTLCISV LLALTFFLLL ISKIVPPTSL DVPLIGKYLM
   301  FTMVLVTFSI VTSVCVLNVH HRSPSTHTMA PWVKRCFLHK LPTFLFMKRP GPDSSPARAF
   361  PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP AGSTPVAIPR DFWLRSSGRF
   421  RQDVQEALEG VSFIAQHMKN DDEDQSVVED WKYVAMVVDR LFLWVFMFVC VLGTVGLFLP
   481  PLFQTHAASE GPYAAQRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHRNB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
5.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 5.6 nTPM
  • thymus: 2.7 nTPM
  • retina: 2.6 nTPM
  • adrenal gland: 2.3 nTPM
  • colon: 1 nTPM
  • appendix: 0.6 nTPM

Single-cell type

  • early spermatids: 177 nCPM
  • oocytes: 152 nCPM
  • late spermatids: 135 nCPM
  • late primary spermatocytes: 38 nCPM
  • adrenal medulla cells: 21 nCPM
  • early primary spermatocytes: 11 nCPM

Immune cell

  • memory B-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • midbrain: 5.4 nTPM
  • pons: 4.9 nTPM
  • medulla oblongata: 3.3 nTPM
  • hypothalamus: 2.8 nTPM
  • white matter: 2.7 nTPM
  • cerebral cortex: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHRNB4.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 67 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.14
gnomAD missense Z
1.2
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHRNB4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHRNB4 as an antibody target. Whether an autoantibody or antibody against CHRNB4 could matter depends on whether native CHRNB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHRNB4 is annotated at the cell surface, where native CHRNB4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CHRNB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHRNB4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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