Seroatlas · Human Serome Atlas

SCAMP5

Secretory carrier-associated membrane protein 5

Also known as: MGC24969, SCAM5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAC9
Gene: SCAMP5
Ensembl: ENSG00000198794
Chromosome: 15
Canonical length: 235 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Involved in positive regulation of cytokine production; regulation of vesicle-mediated transport; and response to endoplasmic reticulum stress. Located in Golgi apparatus; plasma membrane; and recycling endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q8TAC9|SCAMP5
     1  MAEKVNNFPP LPKFIPLKPC FYQDFEADIP PQHVSMTKRL YYLWMLNSVT LAVNLVGCLA
    61  WLIGGGGATN FGLAFLWLIL FTPCSYVCWF RPIYKAFKTD SSFSFMAFFF TFMAQLVISI
   121  IQAVGIPGWG VCGWIATISF FGTNIGSAVV MLIPTVMFTV MAVFSFIALS MVHKFYRGSG
   181  GSFSKAQEEW TTGAWKNPHV QQAAQNAAMG AAQGAMNQPQ TQYSATPNYT YSNEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCAMP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 263 nTPM

Expression across tissuesHPA

Tissue

retina: 263 nTPM
cerebral cortex: 200 nTPM
cerebellum: 177 nTPM
hippocampal formation: 117 nTPM
basal ganglia: 111 nTPM
amygdala: 104 nTPM

Single-cell type

rod photoreceptor cells: 513 nCPM
cone photoreceptor cells: 219 nCPM
pdcs: 161 nCPM
retinal bipolar cells: 158 nCPM
brain inhibitory neurons: 135 nCPM
retinal amacrine cells: 124 nCPM

Immune cell

plasmacytoid DC: 28 nTPM
neutrophil: 0.7 nTPM
basophil: 0.4 nTPM
NK-cell: 0.4 nTPM
total PBMC: 0.3 nTPM
memory B-cell: 0.2 nTPM

Brain region

cerebral cortex: 410 nTPM
white matter: 292 nTPM
pons: 278 nTPM
hippocampal formation: 271 nTPM
basal ganglia: 268 nTPM
amygdala: 219 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.65
gnomAD missense Z: 2.05
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-containing complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCAMP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCAMP5 as an antibody target. Whether an autoantibody or antibody against SCAMP5 could matter depends on whether native SCAMP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCAMP5 is annotated at the cell surface, where native SCAMP5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCAMP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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