Seroatlas · Human Serome Atlas

SPRING1

SREBP regulating gene protein

Also known as: C12orf49, FLJ21415, LUR1, POST1, SPRING, SPRNG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H741
Gene: SPRING1
Ensembl: ENSG00000111412
Chromosome: 12
Canonical length: 205 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in positive regulation of SREBP signaling pathway. Located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q9H741|SPRING1
     1  MVNLAAMVWR RLLRKRWVLA LVFGLSLVYF LSSTFKQEER AVRDRNLLQV HDHNQPIPWK
    61  VQFNLGNSSR PSNQCRNSIQ GKHLITDELG YVCERKDLLV NGCCNVNVPS TKQYCCDGCW
   121  PNGCCSAYEY CVSCCLQPNK QLLLERFLNR AAVAFQNLFM AVEDHFELCL AKCRTSSQSV
   181  QHENTYRDPI AKYCYGESPP ELFPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRING1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 35 nTPM
lung: 17 nTPM
choroid plexus: 17 nTPM
kidney: 16 nTPM
salivary gland: 13 nTPM
cerebral cortex: 12 nTPM

Single-cell type

alveolar cells type 1: 214 nCPM
endometrial glandular cells: 132 nCPM
parietal cells: 131 nCPM
alveolar cells type 2: 96 nCPM
epididymal efferent duct ciliated cells: 84 nCPM
transitional alveolar cells: 82 nCPM

Immune cell

memory B-cell: 5.7 nTPM
naive B-cell: 4.9 nTPM
MAIT T-cell: 4.6 nTPM
gdT-cell: 4.5 nTPM
plasmacytoid DC: 4.3 nTPM
eosinophil: 4.1 nTPM

Brain region

thalamus: 38 nTPM
medulla oblongata: 37 nTPM
hypothalamus: 35 nTPM
midbrain: 33 nTPM
pons: 33 nTPM
basal ganglia: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0.01
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of SREBP signaling pathway

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

SREBP regulating gene protein
SREBP regulating gene protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPRING1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRING1 as an antibody target. Whether an autoantibody or antibody against SPRING1 could matter depends on whether native SPRING1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRING1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRING1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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