Seroatlas · Human Serome Atlas

CLIP2

CAP-Gly domain-containing linker protein 2

Also known as: CLIP, CLIP-115, CLIP2_HUMAN, CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR3, WSCR4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UDT6
Gene
CLIP2
Ensembl
ENSG00000106665
Chromosome
7
Canonical length
1046 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1046 residues, UniProt reviewed canonical sequence.

>Q9UDT6|CLIP2
     1  MQKPSGLKPP GRGGKHSSPM GRTSTGSASS SAAVAASSKE GSPLHKQSSG PSSSPAAAAA
    61  PEKPGPKAAE VGDDFLGDFV VGERVWVNGV KPGVVQYLGE TQFAPGQWAG VVLDDPVGKN
   121  DGAVGGVRYF ECPALQGIFT RPSKLTRQPT AEGSGSDAHS VESLTAQNLS LHSGTATPPL
   181  TSRVIPLRES VLNSSVKTGN ESGSNLSDSG SVKRGEKDLR LGDRVLVGGT KTGVVRYVGE
   241  TDFAKGEWCG VELDEPLGKN DGAVAGTRYF QCPPKFGLFA PIHKVIRIGF PSTSPAKAKK
   301  TKRMAMGVSA LTHSPSSSSI SSVSSVASSV GGRPSRSGLL TETSSRYARK ISGTTALQEA
   361  LKEKQQHIEQ LLAERDLERA EVAKATSHIC EVEKEIALLK AQHEQYVAEA EEKLQRARLL
   421  VESVRKEKVD LSNQLEEERR KVEDLQFRVE EESITKGDLE TQTQLEHARI GELEQSLLLE
   481  KAQAERLLRE LADNRLTTVA EKSRVLQLEE ELTLRRGEIE ELQQCLLHSG PPPPDHPDAA
   541  EILRLRERLL SASKEHQRES GVLRDKYEKA LKAYQAEVDK LRAANEKYAQ EVAGLKDKVQ
   601  QATSENMGLM DNWKSKLDSL ASDHQKSLED LKATLNSGPG AQQKEIGELK AVMEGIKMEH
   661  QLELGNLQAK HDLETAMHVK EKEALREKLQ EAQEELAGLQ RHWRAQLEVQ ASQHRLELQE
   721  AQDQRRDAEL RVHELEKLDV EYRGQAQAIE FLKEQISLAE KKMLDYERLQ RAEAQGKQEV
   781  ESLREKLLVA ENRLQAVEAL CSSQHTHMIE SNDISEETIR TKETVEGLQD KLNKRDKEVT
   841  ALTSQTEMLR AQVSALESKC KSGEKKVDAL LKEKRRLEAE LETVSRKTHD ASGQLVLISQ
   901  ELLRKERSLN ELRVLLLEAN RHSPGPERDL SREVHKAEWR IKEQKLKDDI RGLREKLTGL
   961  DKEKSLSDQR RYSLIDRSSA PELLRLQHQL MSTEDALRDA LDQAQQVEKL MEAMRSCPDK
  1021  AQTIGNSGSA NGIHQQDKAQ KQEDKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 78 nTPM
  • midbrain: 68 nTPM
  • amygdala: 60 nTPM
  • hippocampal formation: 60 nTPM
  • cerebral cortex: 59 nTPM
  • hypothalamus: 52 nTPM

Single-cell type

  • endometrial luminal cells: 275 nCPM
  • oligodendrocytes: 172 nCPM
  • platelets: 161 nCPM
  • basal keratinocytes: 155 nCPM
  • colonocytes: 150 nCPM
  • oligodendrocyte progenitor cells: 139 nCPM

Immune cell

  • basophil: 0.8 nTPM
  • memory B-cell: 0.7 nTPM
  • intermediate monocyte: 0.6 nTPM
  • classical monocyte: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • total PBMC: 0.3 nTPM

Brain region

  • medulla oblongata: 178 nTPM
  • white matter: 176 nTPM
  • pons: 165 nTPM
  • basal ganglia: 161 nTPM
  • midbrain: 160 nTPM
  • spinal cord: 145 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
2.36
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLIP2 as an antibody target. Whether an autoantibody or antibody against CLIP2 could matter depends on whether native CLIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLIP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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