SKIDA1

Protein identityUniProt · HPA

UniProt accession

Q1XH10

Gene

SKIDA1

Ensembl

ENSG00000180592

Chromosome

10

Canonical length

908 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

908 residues, UniProt reviewed canonical sequence.

>Q1XH10|SKIDA1
     1  MGDLKSGFEE VDGVRLGYLI IKGKQMFALS QVFTDLLKNI PRTTVHKRMD HLKVKKHHCD
    61  LEELRKLKAI NSIAFHAAKC TLISREDVEA LYTSCKTERV LKTKRRRVGR ALATKAPPPE
   121  RAAAASPRPG FWKDKHQLWR GLSGAARPLP ISAQSQRPGA AAARPAAHLP QIFSKYPGSH
   181  YPEIVRSPCK PPLNYETAPL QGNYVAFPSD PAYFRSLLCS KHPAAAAAAA AAAAAAAAAA
   241  AAAAYYQVSA AGPQPKAAAG AGGPGSLSYR CKRKRGGAKD CLLAPHAGAR RLLLLPRSYK
   301  AKAAAAAAAA AAAAAAAAGA TCLERFHLVN GFCPPPHHHH HHHHHHHHHH HRAQPPQQSH
   361  HPPHHHRPQP HLGSFPESCS SDSESSSYSD HAANDSDFGS SLSSSSNSVS SEEEEEEGEE
   421  EEEEEEEEGG SGASDSSEVS SEEEDSSTES DSSSGSSQVS VQSIRFRRTS FCKPPSVQAQ
   481  ANFLYHLASA AAATKPAAFE DAGRLPDLKS SVKAESPAEW NLQSWAPKAS PVYCPASLGS
   541  CFAEIRNDRV SEITFPHSEI SNAVKRTDLT INCLAEGASS PSPKTNNAFP QQRILREARK
   601  CLQTTPTTHC ADNNTIAARF LNNDSSGAEA NSEKYSKILH CPEFATDLPS SQTDPEVNAA
   661  GAAATKAENP CTDTGDKTLP FLHNIKIKVE DSSANEEYEP HLFTNKLKCE CNDTKGEFYS
   721  VTESKEEDAL LTTAKEGFAC PEKETPSLNP LAQSQGLSCT LGSPKPEDGE YKFGARVRKN
   781  YRTLVLGKRP VLQTPPVKPN LKSARSPRPT GKTETNEGTL DDFTVINRRK KVASNVASAV
   841  KRPFHFMANF PCPPSLIIGR DGDLWPAYSL NTTKDSQTPH KAHPIWKWQL GGSAIPLPPS
   901  HKFRKFNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SKIDA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

1.6 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

0.99

gnomAD missense Z

1.16

DepMap mean gene effect

0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity

Protein domainsUniProt · Pfam · InterPro

• SKI/SNO/DAC domain
• Putative DNA-binding domain superfamily
• Elongin BC and Polycomb repressive complex 2-associated protein EPOP-like
• Ski-like, DNA-binding domain superfamily
• Elongin BC-PRC2 Interaction & Viral Restriction
• SKI/SNO/DAC Dachshund homology domain
• Elongin BC and Polycomb repressive complex 2-associated protein

KeywordsUniProt

• Alternative initiation
• Isopeptide bond
• Ubl conjugation