Seroatlas · Human Serome Atlas

SKA2

Spindle and kinetochore-associated protein 2

Also known as: FAM33A, FLJ12758, SKA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVK7
Gene: SKA2
Ensembl: ENSG00000182628
Chromosome: 17
Canonical length: 121 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables microtubule binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore and regulation of microtubule polymerization or depolymerization. Located in kinetochore and spindle microtubule. Part of SKA complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>Q8WVK7|SKA2
     1  MEAEVDKLEL MFQKAESDLD YIQYRLEYEI KTNHPDSASE KNPVTLLKEL SVIKSRYQTL
    61  YARFKPVAVE QKESKSRICA TVKKTMNMIQ KLQKQTDLEL SPLTKEEKTA AEQFKFHMPD
   121  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SKA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 54 nTPM
thymus: 50 nTPM
spinal cord: 45 nTPM
retina: 41 nTPM
midbrain: 39 nTPM
amygdala: 36 nTPM

Single-cell type

esophageal apical cells: 164 nCPM
megakaryocytes: 130 nCPM
esophageal basal cells: 107 nCPM
monocyte progenitors: 105 nCPM
sertoli cells: 100 nCPM
migrating cytotrophoblasts: 92 nCPM

Immune cell

T-reg: 49 nTPM
non-classical monocyte: 39 nTPM
basophil: 29 nTPM
memory CD4 T-cell: 26 nTPM
memory CD8 T-cell: 24 nTPM
intermediate monocyte: 24 nTPM

Brain region

cerebellum: 63 nTPM
midbrain: 52 nTPM
spinal cord: 51 nTPM
white matter: 51 nTPM
hypothalamus: 49 nTPM
thalamus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -1.02
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Spindle and kinetochore-associated protein 2
Ska2, N-terminal
Spindle and kinetochore-associated protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SKA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SKA2 as an antibody target. Whether an autoantibody or antibody against SKA2 could matter depends on whether native SKA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SKA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SKA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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