Seroatlas · Human Serome Atlas

PALM3

Paralemmin-3

Also known as: PALM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NDB9
Gene
PALM3
Ensembl
ENSG00000187867
Chromosome
19
Canonical length
673 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Plasma membrane

OverviewNCBI Gene

Predicted to enable ATP binding activity. Involved in Toll signaling pathway; negative regulation of cytokine-mediated signaling pathway; and response to lipopolysaccharide. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>A6NDB9|PALM3
     1  MAESSLYRQR LEVIAEKRRL QEEIRAARRE VEEEKLRVER LKRKSLRERW LMDGAAAVPE
    61  PSEDPTSKDP QSPEGQAQAR IRNLEDSLFT LQSQLQLLQS ASTGAQHKPS GRPSWRRQGH
   121  RPLSQSIVEA GSVGQTDLNK RASLPAGLVG TPPESPSEPR EDVLGFLPGP RQVPGAAGDS
   181  SEANGPCPSP IPTPEQGLSQ RAVPSEGRVG EAKGGGVVSV VWEGLRATED CATGATGPEL
   241  EAKVEEVVLE AIGDRKGAGS LELPAWVKED RGIVEVVWEG VGGSDAEAMG EIGRVPEVVQ
   301  TSSPRLQERL EAAASIEGED VPQGSPEGDG QGGSGGEEGS FIWVERVTLS EEWEELLVEG
   361  LEGPEVAGRE RGDESPLGAE GAKTGGGEET WEAEKRKAEE SMGIGSEEKP GTGRDEAEMS
   421  PVVERKGGEK KLELESRGSA EKLGTEREGG EEPLGIERKV EGHLRAEKEG DEEKRGAEEE
   481  EVEEPLGVEK KGGEEEPEAT KEPLEAERKG GEETLEAEKR GGEESLETEK TQGTEGDLNL
   541  EQGSREGSES QAEEMNEAGP PLEANTETRP EKEGPQPQEK PVGALEEEGV KPQTAAEGQG
   601  PLGDATPLLA ETPAPEQPAE CQPLLQGEGP SANPSAHPVP TYAPARQPEP SAPTEGEEAS
   661  GPKQKTCQCC AVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PALM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • liver: 55 nTPM
  • kidney: 45 nTPM
  • stomach: 29 nTPM
  • pancreas: 25 nTPM
  • testis: 13 nTPM
  • thyroid gland: 12 nTPM

Single-cell type

  • proximal tubule cells: 35 nCPM
  • renal connecting tubule cells: 31 nCPM
  • renal collecting duct principal cells: 27 nCPM
  • loop of henle epithelial cells: 21 nCPM
  • renal collecting duct intercalated cells: 20 nCPM
  • papillary tip epithelial cells: 18 nCPM

Immune cell

  • naive CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • pons: 4.3 nTPM
  • medulla oblongata: 3.3 nTPM
  • hypothalamus: 2.3 nTPM
  • midbrain: 2 nTPM
  • spinal cord: 2 nTPM
  • white matter: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.48
gnomAD missense Z
1.32
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PALM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PALM3 as an antibody target. Whether an autoantibody or antibody against PALM3 could matter depends on whether native PALM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PALM3 is annotated at the cell surface, where native PALM3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PALM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PALM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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