Seroatlas · Human Serome Atlas

WNT4

Protein Wnt-4

Also known as: WNT-4, WNT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P56705
Gene
WNT4
Ensembl
ENSG00000162552
Chromosome
1
Canonical length
351 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>P56705|WNT4
     1  MSPRSCLRSL RLLVFAVFSA AASNWLYLAK LSSVGSISEE ETCEKLKGLI QRQVQMCKRN
    61  LEVMDSVRRG AQLAIEECQY QFRNRRWNCS TLDSLPVFGK VVTQGTREAA FVYAISSAGV
   121  AFAVTRACSS GELEKCGCDR TVHGVSPQGF QWSGCSDNIA YGVAFSQSFV DVRERSKGAS
   181  SSRALMNLHN NEAGRKAILT HMRVECKCHG VSGSCEVKTC WRAVPPFRQV GHALKEKFDG
   241  ATEVEPRRVG SSRALVPRNA QFKPHTDEDL VYLEPSPDFC EQDMRSGVLG TRGRTCNKTS
   301  KAIDGCELLC CGRGFHTAQV ELAERCSCKF HWCCFVKCRQ CQRLVELHTC R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • skin: 39 nTPM
  • ovary: 16 nTPM
  • esophagus: 11 nTPM
  • adrenal gland: 8.5 nTPM
  • epididymis: 8.4 nTPM
  • fallopian tube: 7.8 nTPM

Single-cell type

  • pancreatic islet cells: 224 nCPM
  • endometrial stromal cells: 64 nCPM
  • respiratory basal cells: 62 nCPM
  • ocular epithelial cells: 55 nCPM
  • breast hormone-responsive cells: 53 nCPM
  • suprabasal keratinocytes: 38 nCPM

Immune cell

  • eosinophil: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 9.9 nTPM
  • basal ganglia: 7.2 nTPM
  • cerebral cortex: 6.2 nTPM
  • midbrain: 6 nTPM
  • thalamus: 6 nTPM
  • medulla oblongata: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WNT4.

Disease | AllUniProt

Conditions WNT4 is implicated in, by any mechanism.

  • 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) MIM:611812
  • Mullerian aplasia and hyperandrogenism (MULLAPL) MIM:158330

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 173 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Mullerian aplasia and hyperandrogenism
  • SERKAL syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.13
gnomAD missense Z
1.61
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WNT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT4 as an antibody target. Whether an autoantibody or antibody against WNT4 could matter depends on whether native WNT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT4 is annotated as secreted, so native WNT4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WNT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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