Seroatlas · Human Serome Atlas

ZDHHC6

Palmitoyltransferase ZDHHC6

Also known as: FLJ21952, ZDHC6_HUMAN, ZNF376

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H6R6
Gene
ZDHHC6
Ensembl
ENSG00000023041
Chromosome
10
Canonical length
413 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Involved in positive regulation of mitochondrial fusion; protein palmitoylation; and protein stearoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>Q9H6R6|ZDHHC6
     1  MGTFCSVIKF ENLQELKRLC HWGPIIALGV IAICSTMAMI DSVLWYWPLH TTGGSVNFIM
    61  LINWTVMILY NYFNAMFVGP GFVPLGWKPE ISQDTMYLQY CKVCQAYKAP RSHHCRKCNR
   121  CVMKMDHHCP WINNCCGYQN HASFTLFLLL APLGCIHAAF IFVMTMYTQL YHRLSFGWNT
   181  VKIDMSAARR DPLPIVPFGL AAFATTLFAL GLALGTTIAV GMLFFIQMKI ILRNKTSIES
   241  WIEEKAKDRI QYYQLDEVFV FPYDMGSRWR NFKQVFTWSG VPEGDGLEWP VREGCHQYSL
   301  TIEQLKQKAD KRVRSVRYKV IEDYSGACCP LNKGIKTFFT SPCTEEPRIQ LQKGEFILAT
   361  RGLRYWLYGD KILDDSFIEG VSRIRGWFPR KCVEKCPCDA ETDQAPEGEK KNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 40 nTPM
  • small intestine: 31 nTPM
  • duodenum: 28 nTPM
  • liver: 25 nTPM
  • choroid plexus: 24 nTPM
  • epididymis: 21 nTPM

Single-cell type

  • podocytes: 902 nCPM
  • cardiomyocytes: 172 nCPM
  • esophageal apical cells: 160 nCPM
  • early spermatids: 119 nCPM
  • epicardial cells: 105 nCPM
  • endometrial glandular cells: 100 nCPM

Immune cell

  • T-reg: 21 nTPM
  • eosinophil: 19 nTPM
  • MAIT T-cell: 17 nTPM
  • classical monocyte: 16 nTPM
  • memory CD8 T-cell: 16 nTPM
  • myeloid DC: 16 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • white matter: 17 nTPM
  • thalamus: 17 nTPM
  • hypothalamus: 15 nTPM
  • cerebellum: 15 nTPM
  • cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC6 as an antibody target. Whether an autoantibody or antibody against ZDHHC6 could matter depends on whether native ZDHHC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZDHHC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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