Mir domain superfamily
IPR036300
Definition
This entry represents the MIR domain superfamily. The MIR domain is named after three of the proteins in which it occurs: protein Mannosyltransferase ([ec:2.4.1.109]), Inositol 1,4,5-trisphosphate receptor (IP3R) and Ryanodine receptor (RyR). MIR domains have also been found in eukaryotic stromal cell-derived factor 2 (SDF-2) PMID:28597544 and in Chlamydia trachomatis protein CT153. The MIR domain may have a ligand transferase function. This domain has a closed β-barrel structure with a hairpin triplet, and has an internal pseudo-threefold symmetry. The MIR motifs that make up the MIR domain consist of ~50 residues and are often found in multiple copies. Inositol 1,4,5-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+from intracellular stores by binding to specific Ca2+channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules PMID:1645727. The function is modulated by Ca2+, Mg2+, ATP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) PMID:7829078. protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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