SDCBP2

Protein identityUniProt · HPA

UniProt accession

Q9H190

Gene

SDCBP2

Ensembl

ENSG00000125775

Chromosome

20

Canonical length

292 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q9H190|SDCBP2
     1  MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL ENYMGLSLSS
    61  QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA EIKPGVREIH LCKDERGKTG
   121  LRLRKVDQGL FVQLVQANTP ASLVGLRFGD QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI
   181  VVVVRDRPFQ RTVTMHKDSM GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV
   241  IGLKDKKIME ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDCBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

140 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.38

gnomAD pLI

0

gnomAD missense Z

0.09

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell population proliferation
• intracellular signal transduction
• intracellular transport
• nervous system development

Molecular functions

• identical protein binding
• phosphatidylinositol-4,5-bisphosphate binding
• protein heterodimerization activity
• protein homodimerization activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• Golgi apparatus
• nuclear speck
• nucleolus
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• PDZ domain
• PDZ superfamily
• Amyloid-beta A4 Precursor Protein-Binding
• PDZ domain

KeywordsUniProt

• Cell membrane
• Cytoplasm
• Lipid-binding
• Membrane
• Nucleus
• Repeat

InteractionsUniProt · HPA

Protein binding partners of SDCBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SDCBP
• TM4SF1
• TIFA