Seroatlas · Human Serome Atlas

SDAD1

Protein SDA1 homolog

Also known as: FLJ10498, SDA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVU7
Gene
SDAD1
Ensembl
ENSG00000198301
Chromosome
4
Canonical length
687 aa
Protein class
Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to be involved in ribosomal large subunit biogenesis and ribosomal large subunit export from nucleus. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

687 residues, UniProt reviewed canonical sequence.

>Q9NVU7|SDAD1
     1  MSNRNNNKLP SNLPQLQNLI KRDPPAYIEE FLQQYNHYKS NVEIFKLQPN KPSKELAELV
    61  MFMAQISHCY PEYLSNFPQE VKDLLSCNHT VLDPDLRMTF CKALILLRNK NLINPSSLLE
   121  LFFELFRCHD KLLRKTLYTH IVTDIKNINA KHKNNKVNVV LQNFMYTMLR DSNATAAKMS
   181  LDVMIELYRR NIWNDAKTVN VITTACFSKV TKILVAALTF FLGKDEDEKQ DSDSESEDDG
   241  PTARDLLVQY ATGKKSSKNK KKLEKAMKVL KKQKKKKKPE VFNFSAIHLI HDPQDFAEKL
   301  LKQLECCKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFLQ RFLQPHQREV TKILLFAAQA
   361  SHHLVPPEII QSLLMTVANN FVTDKNSGEV MTVGINAIKE ITARCPLAMT EELLQDLAQY
   421  KTHKDKNVMM SARTLIHLFR TLNPQMLQKK FRGKPTEASI EARVQEYGEL DAKDYIPGAE
   481  VLEVEKEENA ENDEDGWEST SLSEEEDADG EWIDVQHSSD EEQQEISKKL NSMPMEERKA
   541  KAAAISTSRV LTQEDFQKIR MAQMRKELDA APGKSQKRKY IEIDSDEEPR GELLSLRDIE
   601  RLHKKPKSDK ETRLATAMAG KTDRKEFVRK KTKTNPFSSS TNKEKKKQKN FMMMRYSQNV
   661  RSKNKRSFRE KQLALRDALL KKRKRMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 22 nTPM
  • testis: 20 nTPM
  • lymph node: 20 nTPM
  • thyroid gland: 20 nTPM
  • tonsil: 19 nTPM
  • epididymis: 18 nTPM

Single-cell type

  • late spermatids: 156 nCPM
  • differentiating spermatogonia: 153 nCPM
  • early spermatids: 119 nCPM
  • oocytes: 101 nCPM
  • late primary spermatocytes: 101 nCPM
  • undifferentiated spermatogonia: 99 nCPM

Immune cell

  • non-classical monocyte: 28 nTPM
  • MAIT T-cell: 24 nTPM
  • NK-cell: 24 nTPM
  • memory CD4 T-cell: 23 nTPM
  • naive CD4 T-cell: 23 nTPM
  • T-reg: 22 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • hypothalamus: 18 nTPM
  • basal ganglia: 17 nTPM
  • hippocampal formation: 17 nTPM
  • white matter: 16 nTPM
  • medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
-0.03
DepMap mean gene effect
-1.2
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Armadillo-type fold
  • SDA1, middle domain
  • SDA1, N-terminal
  • Sda1
  • SDA1, C-terminal domain
  • SDA1, conserved domain
  • SDA1, HEAT repeat
  • SDA1, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SDAD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDAD1 as an antibody target. Whether an autoantibody or antibody against SDAD1 could matter depends on whether native SDAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SDAD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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