Seroatlas · Human Serome Atlas

SCO1

Protein SCO1 homolog, mitochondrial

Also known as: SCO1_HUMAN, SCOD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75880
Gene: SCO1
Ensembl: ENSG00000133028
Chromosome: 17
Canonical length: 301 aa
Protein class: Disease related genes, Human disease related genes, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>O75880|SCO1
     1  MAMLVLVPGR VMRPLGGQLW RFLPRGLEFW GPAEGTARVL LRQFCARQAE AWRASGRPGY
    61  CLGTRPLSTA RPPPPWSQKG PGDSTRPSKP GPVSWKSLAI TFAIGGALLA GMKHVKKEKA
   121  EKLEKERQRH IGKPLLGGPF SLTTHTGERK TDKDYLGQWL LIYFGFTHCP DVCPEELEKM
   181  IQVVDEIDSI TTLPDLTPLF ISIDPERDTK EAIANYVKEF SPKLVGLTGT REEVDQVARA
   241  YRVYYSPGPK DEDEDYIVDH TIIMYLIGPD GEFLDYFGQN KRKGEIAASI ATHMRPYRKK
   301  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

liver: 29 nTPM
skeletal muscle: 24 nTPM
heart muscle: 23 nTPM
choroid plexus: 20 nTPM
duodenum: 19 nTPM
kidney: 19 nTPM

Single-cell type

extravillous trophoblasts: 158 nCPM
migrating cytotrophoblasts: 93 nCPM
cytotrophoblasts: 78 nCPM
syncytiotrophoblasts: 72 nCPM
parietal cells: 69 nCPM
cone photoreceptor cells: 52 nCPM

Immune cell

non-classical monocyte: 21 nTPM
intermediate monocyte: 19 nTPM
classical monocyte: 16 nTPM
myeloid DC: 15 nTPM
eosinophil: 15 nTPM
T-reg: 14 nTPM

Brain region

choroid plexus: 23 nTPM
thalamus: 14 nTPM
hypothalamus: 14 nTPM
white matter: 14 nTPM
medulla oblongata: 13 nTPM
pons: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCO1.

Disease | AllUniProt

Conditions SCO1 is implicated in, by any mechanism.

Mitochondrial complex IV deficiency, nuclear type 4 (MC4DN4) MIM:619048

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 281 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Mitochondrial complex IV deficiency, nuclear type 4
Mitochondrial complex IV deficiency, nuclear type 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCO1 as an antibody target. Whether an autoantibody or antibody against SCO1 could matter depends on whether native SCO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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