Seroatlas · Human Serome Atlas

TMEM177

Transmembrane protein 177

Also known as: MGC10993, TM177_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53S58
Gene: TMEM177
Ensembl: ENSG00000144120
Chromosome: 2
Canonical length: 311 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q53S58|TMEM177
     1  MAGPLWRTAA FVQRHRTGLL VGSCAGLFGV PISYHLFPDP VVQWLYQYWP QGQPAPLPPQ
    61  LQSLFQEVLQ DIGVPSGHCY KPFTTFTFQP VSAGFPRLPA GAVVGIPASF LGDLVINTNH
   121  PVVIHGHTVD WRSPAGARLR ASLTLSREAQ KFALAREVVY LESSTTAVHA LLAPACLAGT
   181  WALGVGAKYT LGLHAGPMNL RAAFSLVAAV AGFVAYAFSQ DSLTHAVESW LDRRTASLSA
   241  AYACGGVEFY EKLLSGNLAL RSLLGKDGEK LYTPSGNIVP RHLFRIKHLP YTTRRDSVLQ
   301  MWRGMLNPGR S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM177 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

liver: 24 nTPM
duodenum: 15 nTPM
kidney: 14 nTPM
small intestine: 13 nTPM
pituitary gland: 12 nTPM
skeletal muscle: 12 nTPM

Single-cell type

hepatocytes: 37 nCPM
enterocytes: 20 nCPM
epididymal principal cells: 18 nCPM
enteric transient amplifying cells: 17 nCPM
epididymal efferent duct absorptive cells: 17 nCPM
cone photoreceptor cells: 17 nCPM

Immune cell

naive CD4 T-cell: 16 nTPM
naive CD8 T-cell: 10 nTPM
naive B-cell: 8.8 nTPM
MAIT T-cell: 8.5 nTPM
memory CD8 T-cell: 8.5 nTPM
gdT-cell: 8.2 nTPM

Brain region

cerebral cortex: 20 nTPM
cerebellum: 20 nTPM
hippocampal formation: 19 nTPM
basal ganglia: 18 nTPM
thalamus: 18 nTPM
amygdala: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0.01
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 177

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM177 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM177 as an antibody target. Whether an autoantibody or antibody against TMEM177 could matter depends on whether native TMEM177 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM177 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM177 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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