COX16

Protein identityUniProt · HPA

UniProt accession

Q9P0S2

Gene

COX16

Ensembl

ENSG00000133983

Chromosome

14

Canonical length

106 aa

Protein class

Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters

Subcellular location

Mitochondria

OverviewNCBI Gene

Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. Implicated in mitochondrial complex IV deficiency nuclear type 22. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>Q9P0S2|COX16
     1  MFAPAVMRAF RKNKTLGYGV PMLLLIVGGS FGLREFSQIR YDAVKSKMDP ELEKKLKENK
    61  ISLESEYEKI KDSKFDDWKN IRGPRPWEDP DLLQGRNPES LKTKTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

79 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COX16.

Disease | AllUniProt

Conditions COX16 is implicated in, by any mechanism.

• Mitochondrial complex IV deficiency, nuclear type 22 (MC4DN22) MIM:619355

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 19 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Mitochondrial complex IV deficiency, nuclear type 22

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.78

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial respiratory chain complex IV assembly

Cellular components

• mitochondrial inner membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Cytochrome c oxidase assembly protein COX16
• Cytochrome c oxidase assembly protein COX16

KeywordsUniProt

• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Primary mitochondrial disease
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of COX16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• COA6
• SCO1
• SCO2
• MT-CO2