Seroatlas · Human Serome Atlas

METTL6

tRNA N(3)-cytidine methyltransferase METTL6

Also known as: METL6_HUMAN, MGC24132

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCB7
Gene: METTL6
Ensembl: ENSG00000206562
Chromosome: 3
Canonical length: 284 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables enzyme binding activity and tRNA (cytidine-3-)-methyltransferase activity. Involved in tRNA methylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>Q8TCB7|METTL6
     1  MASLQRKGLQ ARILTSEEEE KLKRDQTLVS DFKQQKLEQE AQKNWDLFYK RNSTNFFKDR
    61  HWTTREFEEL RSCREFEDQK LTMLEAGCGV GNCLFPLLEE DPNIFAYACD FSPRAIEYVK
   121  QNPLYDTERC KVFQCDLTKD DLLDHVPPES VDVVMLIFVL SAVHPDKMHL VLQNIYKVLK
   181  PGKSVLFRDY GLYDHAMLRF KASSKLGENF YVRQDGTRSY FFTDDFLAQL FMDTGYEEVV
   241  NEYVFRETVN KKEGLCVPRV FLQSKFLKPP KNPSPVVLGL DPKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
cerebral cortex: 14 nTPM
retina: 12 nTPM
ovary: 12 nTPM
spinal cord: 11 nTPM
hypothalamus: 11 nTPM

Single-cell type

early spermatids: 264 nCPM
late primary spermatocytes: 179 nCPM
late spermatids: 160 nCPM
epicardial cells: 136 nCPM
cardiomyocytes: 91 nCPM
brain inhibitory neurons: 69 nCPM

Immune cell

plasmacytoid DC: 12 nTPM
eosinophil: 12 nTPM
NK-cell: 12 nTPM
intermediate monocyte: 11 nTPM
non-classical monocyte: 11 nTPM
naive CD8 T-cell: 9.9 nTPM

Brain region

white matter: 40 nTPM
cerebral cortex: 37 nTPM
hypothalamus: 36 nTPM
cerebellum: 36 nTPM
basal ganglia: 36 nTPM
hippocampal formation: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SARS1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL6 as an antibody target. Whether an autoantibody or antibody against METTL6 could matter depends on whether native METTL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...