Seroatlas · Human Serome Atlas

DUS3L

tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

Also known as: DUS3, DUS3L_HUMAN, FLJ13896

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96G46
Gene: DUS3L
Ensembl: ENSG00000141994
Chromosome: 19
Canonical length: 650 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables mRNA dihydrouridine synthase activity and tRNA-dihydrouridine47 synthase activity. Involved in regulation of translation and tRNA dihydrouridine synthesis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

650 residues, UniProt reviewed canonical sequence.

>Q96G46|DUS3L
     1  MAEGTAEAPL ENGGGGDSGA GALERGVAPI KRQYLTTKEQ FHQFLEAKGQ EKTCRETEVG
    61  DPAGNELAEP EAKRIRLEDG QTADGQTEEA AEPGEQLQTQ KRARGQNKGR PHVKPTNYDK
   121  NRLCPSLIQE SAAKCFFGDR CRFLHDVGRY LETKPADLGP RCVLFETFGR CPYGVTCRFA
   181  GAHLRPEGQN LVQEELAARG TQPPSIRNGL DKALQQQLRK REVRFERAEQ ALRRFSQGPT
   241  PAAAVPEGTA AEGAPRQENC GAQQVPAGPG TSTPPSSPVR TCGPLTDEDV VRLRPCEKKR
   301  LDIRGKLYLA PLTTCGNLPF RRICKRFGAD VTCGEMAVCT NLLQGQMSEW ALLKRHQCED
   361  IFGVQLEGAF PDTMTKCAEL LSRTVEVDFV DINVGCPIDL VYKKGGGCAL MNRSTKFQQI
   421  VRGMNQVLDV PLTVKIRTGV QERVNLAHRL LPELRDWGVA LVTLHGRSRE QRYTKLADWQ
   481  YIEECVQAAS PMPLFGNGDI LSFEDANRAM QTGVTGIMIA RGALLKPWLF TEIKEQRHWD
   541  ISSSERLDIL RDFTNYGLEH WGSDTQGVEK TRRFLLEWLS FLCRYVPVGL LERLPQRINE
   601  RPPYYLGRDY LETLMASQKA ADWIRISEML LGPVPPSFAF LPKHKANAYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUS3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

testis: 39 nTPM
liver: 25 nTPM
skin: 25 nTPM
pancreas: 24 nTPM
esophagus: 21 nTPM
spleen: 20 nTPM

Single-cell type

late primary spermatocytes: 130 nCPM
esophageal basal cells: 35 nCPM
early spermatids: 33 nCPM
migrating cytotrophoblasts: 32 nCPM
syncytiotrophoblasts: 31 nCPM
paneth cells: 31 nCPM

Immune cell

plasmacytoid DC: 31 nTPM
intermediate monocyte: 30 nTPM
myeloid DC: 30 nTPM
NK-cell: 28 nTPM
non-classical monocyte: 26 nTPM
MAIT T-cell: 25 nTPM

Brain region

white matter: 16 nTPM
medulla oblongata: 15 nTPM
cerebral cortex: 14 nTPM
thalamus: 13 nTPM
midbrain: 12 nTPM
pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 1.53
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

flavin adenine dinucleotide binding
RNA binding
tRNA dihydrouridine synthase activity
zinc ion binding
mRNA dihydrouridine synthase activity
tRNA-dihydrouridine47 synthase activity

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCCH-type
Aldolase-type TIM barrel
tRNA-dihydrouridine synthase, conserved site
DUS-like, FMN-binding domain
Dihydrouridine synthase (Dus)
DUS3L CCCH zinc finger domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DUS3L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SARS1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUS3L as an antibody target. Whether an autoantibody or antibody against DUS3L could matter depends on whether native DUS3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUS3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUS3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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