Seroatlas · Human Serome Atlas

RSPH10B2

Radial spoke head 10 homolog B2

Also known as: R10B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B2RC85
Gene: RSPH10B2
Ensembl: ENSG00000169402
Chromosome: 7
Canonical length: 870 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Microtubules,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a protein component of the radial spoke head in flagella and motile cilia. Eukaryotic flagella and motile cilia share a common 9 + 2 structure, in which nine peripheral microtubule doublets (MTDs) surround a central-pair of microtubules (CP), with radial spokes connecting the MTDs to the CP. The radial spoke is a multi-protein complex that works as a mechanochemical transducer between the CP and the MTDs. The radial spoke contributes to the regulation of the activity of dynein motors, and thus to flagellar motility. PMID: 22754630 provides a good review of radial spokes. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

870 residues, UniProt reviewed canonical sequence.

>B2RC85|RSPH10B2
     1  MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM QLNEVKPKKD
    61  RQNVQQNEDA SQYEESILTK LIVESYEGEK VRGLYEGEGF AAFQGGCTYR GMFSEGLMHG
   121  QGTYIWADGL KYEGDFVKNV PMNHGVYTWP DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI
   181  GHWCNGKRHG KGSIYYNQEG TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG
   241  RMRWLTTNEE YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY
   301  YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI SCLDLSSGVA
   361  PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET VQPEEKKQVE YAVLRNITEL
   421  RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF LKDCKFHHHK LTLADMDRIL SANNDIPVEE
   481  IHSPFTTILL RTFLNYLLHL AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NACQIKGNLF
   541  REQQRTLYSM SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF
   601  MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN VPADDVSGNK
   661  HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL ELSPDVNKIR KSEPKIKKSV
   721  SHERVSKMNF KLTGKGITFF SSESKKYERP KDDREEEFNT WVNNTYVFFV NTLFHAYKRE
   781  EAIKEKIRAD RLRSTAQAQQ RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV
   841  SSSHLILDPP KEDVTVSPSS KTITSKKKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSPH10B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

testis: 18 nTPM
fallopian tube: 9.5 nTPM
choroid plexus: 3.5 nTPM
lung: 1.3 nTPM
parathyroid gland: 1.1 nTPM
hippocampal formation: 0.7 nTPM

Single-cell type

late spermatids: 113 nCPM
early spermatids: 29 nCPM
ependymal cells: 29 nCPM
respiratory ciliated cells: 25 nCPM
late primary spermatocytes: 23 nCPM
fallopian tube ciliated cells: 22 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 10 nTPM
midbrain: 9.1 nTPM
medulla oblongata: 6.1 nTPM
spinal cord: 3.9 nTPM
pons: 3.1 nTPM
hypothalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.02
gnomAD missense Z: 1.58

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSPH10B2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RSPH6A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSPH10B2 as an antibody target. Whether an autoantibody or antibody against RSPH10B2 could matter depends on whether native RSPH10B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSPH10B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSPH10B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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