Seroatlas · Human Serome Atlas

RSPH10B

Radial spoke head 10 homolog B

Also known as: R10B1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C881
Gene: RSPH10B
Ensembl: ENSG00000155026
Chromosome: 7
Canonical length: 870 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Microtubules,Primary cilium,Cytosol

OverviewNCBI Gene

Predicted to enable kinase activity. Located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

870 residues, UniProt reviewed canonical sequence.

>P0C881|RSPH10B
     1  MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM QLNEVKPKKD
    61  RQNVQQNEDA TQYEESILTK LIVESYEGEK VRGLYEGEGF AAFQGGCTYR GMFSEGLMHG
   121  QGTYIWADGL KYEGDFVKNV PMNHGVYTWP DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI
   181  GHWCNGKRHG KGSIYYNQEG TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG
   241  RMRWLTTNEE YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY
   301  YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI SCLDLSSGVA
   361  PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET VQPEEKKQVE YAVLRNITEL
   421  RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF LKDCKFHHHK LTLADMDRIL SANNDIPVEE
   481  IHSPFTTILL RTFLNYLLHL AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NAFQIKGNLF
   541  REQQRTLYSM SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF
   601  MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN VPADDVSGNK
   661  HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL ELSPDVNKIR KSEPKIKKSV
   721  SHERVSKMNF KLTGKGITFF SSESKKYERP KDDREEEFNT WVNNMYVFFV NTLFHAYKRE
   781  EAIKEKIRAD RLRSTAQAQQ RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV
   841  SSSHLILDPP KEDVTVSPSS KTITSKKKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSPH10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

testis: 18 nTPM
fallopian tube: 7.9 nTPM
choroid plexus: 4 nTPM
hypothalamus: 1.4 nTPM
hippocampal formation: 1.3 nTPM
lung: 1.2 nTPM

Single-cell type

late spermatids: 236 nCPM
early spermatids: 58 nCPM
late primary spermatocytes: 38 nCPM
respiratory ciliated cells: 31 nCPM
fallopian tube ciliated cells: 21 nCPM
epididymal efferent duct ciliated cells: 18 nCPM

Immune cell

memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 8.4 nTPM
midbrain: 7.1 nTPM
medulla oblongata: 5.4 nTPM
spinal cord: 4.6 nTPM
hypothalamus: 3.7 nTPM
pons: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 0.37

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSPH10B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RSPH6A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSPH10B as an antibody target. Whether an autoantibody or antibody against RSPH10B could matter depends on whether native RSPH10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSPH10B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSPH10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...