FDPS

Protein identityUniProt · HPA

UniProt accession

P14324

Gene

FDPS

Ensembl

ENSG00000160752

Chromosome

1

Canonical length

419 aa

Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>P14324|FDPS
     1  MPLSRWLRSV GVFLLPAPYW APRERWLGSL RRPSLVHGYP VLAWHSARCW CQAWTEEPRA
    61  LCSSLRMNGD QNSDVYAQEK QDFVQHFSQI VRVLTEDEMG HPEIGDAIAR LKEVLEYNAI
   121  GGKYNRGLTV VVAFRELVEP RKQDADSLQR AWTVGWCVEL LQAFFLVADD IMDSSLTRRG
   181  QICWYQKPGV GLDAINDANL LEACIYRLLK LYCREQPYYL NLIELFLQSS YQTEIGQTLD
   241  LLTAPQGNVD LVRFTEKRYK SIVKYKTAFY SFYLPIAAAM YMAGIDGEKE HANAKKILLE
   301  MGEFFQIQDD YLDLFGDPSV TGKIGTDIQD NKCSWLVVQC LQRATPEQYQ ILKENYGQKE
   361  AEKVARVKAL YEELDLPAVF LQYEEDSYSH IMALIEQYAA PLPPAVFLGL ARKIYKRRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FDPS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

333 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FDPS.

Disease | AllUniProt

Conditions FDPS is implicated in, by any mechanism.

• Porokeratosis 9, multiple types (POROK9) MIM:616631

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 99 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Porokeratosis 9, multiple types

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.63

gnomAD pLI

0.01

gnomAD missense Z

1.09

DepMap mean gene effect

-0.67

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cholesterol biosynthetic process
• farnesyl diphosphate biosynthetic process
• geranyl diphosphate biosynthetic process

Molecular functions

• (2E,6E)-farnesyl diphosphate synthase activity
• dimethylallyltranstransferase activity
• metal ion binding
• RNA binding

Cellular components

• cytoplasm
• cytosol
• mitochondrial matrix
• nucleoplasm
• peroxisome

Protein domainsUniProt · Pfam · InterPro

• Polyprenyl synthetase-like
• Isoprenoid synthase domain superfamily
• Polyprenyl synthetase, conserved site
• Polyprenyl synthetase
• Farnesyl pyrophosphate synthase-like

KeywordsUniProt

• Acetylation
• Cholesterol biosynthesis
• Cholesterol metabolism
• Cytoplasm
• Host-virus interaction
• Hydroxylation
• Isoprene biosynthesis
• Lipid biosynthesis
• Lipid metabolism
• Magnesium
• Metal-binding
• Steroid biosynthesis
• Steroid metabolism
• Sterol biosynthesis
• Sterol metabolism
• Transferase

InteractionsUniProt · HPA

Protein binding partners of FDPS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RSAD2