Seroatlas · Human Serome Atlas

RPP40

Ribonuclease P protein subunit p40

Also known as: bA428J1.3, RNASEP1, RPP40_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75818
Gene: RPP40
Ensembl: ENSG00000124787
Chromosome: 6
Canonical length: 363 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>O75818|RPP40
     1  MATLRRLREA PRHLLVCEKS NFGNHKSRHR HLVQTHYYNY RVSFLIPECG ILSEELKNLV
    61  MNTGPYYFVK NLPLHELITP EFISTFIKKG SCYALTYNTH IDEDNTVALL PNGKLILSLD
   121  KDTYEETGLQ GHPSQFSGRK IMKFIVSIDL MELSLNLDSK KYERISWSFK EKKPLKFDFL
   181  LAWHKTGSEE STMMSYFSKY QIQEHQPKVA LSTLRDLQCP VLQSSELEGT PEVSCRALEL
   241  FDWLGAVFSN VDLNNEPNNF ISTYCCPEPS TVVAKAYLCT ITGFILPEKI CLLLEHLCHY
   301  FDEPKLAPWV TLSVQGFADS PVSWEKNEHG FRKGGEHLYN FVIFNNQDYW LQMAVGANDH
   361  CPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPP40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 11 nTPM
esophagus: 8.4 nTPM
urinary bladder: 7.5 nTPM
liver: 7 nTPM
breast: 6.2 nTPM
skin: 5.8 nTPM

Single-cell type

oocytes: 120 nCPM
esophageal basal cells: 42 nCPM
esophageal suprabasal cells: 35 nCPM
gastric progenitor cells: 33 nCPM
differentiating spermatogonia: 32 nCPM
decidual stromal cells: 30 nCPM

Immune cell

myeloid DC: 13 nTPM
intermediate monocyte: 12 nTPM
T-reg: 9.2 nTPM
NK-cell: 8.7 nTPM
memory B-cell: 8.1 nTPM
naive CD4 T-cell: 7.6 nTPM

Brain region

hypothalamus: 5.6 nTPM
white matter: 4.3 nTPM
pons: 4.2 nTPM
cerebral cortex: 4.1 nTPM
spinal cord: 4 nTPM
midbrain: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.88
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribonuclease P protein subunit Rpp40
Ribonuclease P 40kDa (Rpp40) subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPP40 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPP40 as an antibody target. Whether an autoantibody or antibody against RPP40 could matter depends on whether native RPP40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPP40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPP40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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