Seroatlas · Human Serome Atlas

FSCB

Fibrous sheath CABYR-binding protein

Also known as: C14orf155, DKFZP434F1017, FSCB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9T9
Gene: FSCB
Ensembl: ENSG00000189139
Chromosome: 14
Canonical length: 825 aa
Protein class: Predicted intracellular proteins
Subcellular location: Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of protein sumoylation. Predicted to be located in motile cilium. Predicted to be active in sperm fibrous sheath and sperm principal piece. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

825 residues, UniProt reviewed canonical sequence.

>Q5H9T9|FSCB
     1  MVGKSQQTDV IEKKKHMAIP KSSSPKATHR IGNTSGSKGS YSAKAYESIR VSSELQQTWT
    61  KRKHGQEMTS KSLQTDTIVE EKKEVKLVEE TVVPEEKSAD VREAAIELPE SVQDVEIPPN
   121  IPSVQLKMDR SQQTSRTGYW TMMNIPPVEK VDKEQQTYFS ESEIVVISRP DSSSTKSKED
   181  ALKHKSSGKI FASEHPEFQP ATNSNEEIGQ KNISRTSFTQ ETKKGPPVLL EDELREEVTV
   241  PVVQEGSAVK KVASAEIEPP STEKFPAKIQ PPLVEEATAK AEPRPAEETH VQVQPSTEET
   301  PDAEAATAVA ENSVKVQPPP AEEAPLVEFP AEIQPPSAEE SPSVELLAEI LPPSAEESPS
   361  EEPPAEILPP PAEKSPSVEL LGEIRSPSAQ KAPIEVQPLP AEGALEEAPA KVEPPTVEET
   421  LADVQPLLPE EAPREEAREL QLSTAMETPA EEAPTEFQSP LPKETTAEEA SAEIQLLAAT
   481  EPPADETPAE ARSPLSEETS AEEAHAEVQS PLAEETTAEE ASAEIQLLAA IEAPADETPA
   541  EAQSPLSEET SAEEAPAEVQ SPSAKGVSIE EAPLELQPPS GEETTAEEAS AAIQLLAATE
   601  ASAEEAPAEV QPPPAEEAPA EVQPPPAEEA PAEVQPPPAE EAPAEVQPPP AEEAPAEVQP
   661  PPAEEAPAEV QPPPAEEAPA EVQSLPAEET PIEETLAAVH SPPADDVPAE EASVDKHSPP
   721  ADLLLTEEFP IGEASAEVSP PPSEQTPEDE ALVENVSTEF QSPQVAGIPA VKLGSVVLEG
   781  EAKFEEVSKI NSVLKDLSNT NDGQAPTLEI ESVFHIELKQ RPPEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSCB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 1,313 nCPM
early spermatids: 341 nCPM
late primary spermatocytes: 176 nCPM
sertoli cells: 8.1 nCPM
choroid plexus epithelial cells: 3.9 nCPM
leydig cells: 2.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 2.5 nTPM
white matter: 1.1 nTPM
thalamus: 0.4 nTPM
midbrain: 0.3 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FSCB.

Disease | ImmuneIEDB

Conditions an epitope on FSCB was assayed in.

viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.83
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of protein sumoylation

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Fibrous sheath CABYR-binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FSCB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSCB as an antibody target. Whether an autoantibody or antibody against FSCB could matter depends on whether native FSCB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSCB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSCB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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