Seroatlas · Human Serome Atlas

ANG

Angiogenin

Also known as: ANGI_HUMAN, RAA1, RNASE5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P03950
Gene
ANG
Ensembl
ENSG00000214274
Chromosome
14
Canonical length
147 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Subcellular location
Nucleoli,Nucleoli rim,Mitotic chromosome,Actin filaments
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>P03950|ANG
     1  MVMGLGVLLL VFVLGLGLTP PTLAQDNSRY THFLTQHYDA KPQGRDDRYC ESIMRRRGLT
    61  SPCKDINTFI HGNKRSIKAI CENKNGNPHR ENLRISKSSF QVTTCKLHGG SPWPPCQYRA
   121  TAGFRNVVVA CENGLPVHLD QSIFRRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
2,816 nTPM

Expression across tissuesHPA

Tissue

  • liver: 2,816 nTPM
  • ovary: 56 nTPM
  • stomach: 55 nTPM
  • salivary gland: 51 nTPM
  • rectum: 43 nTPM
  • breast: 36 nTPM

Single-cell type

  • hepatocytes: 29 nCPM
  • myosatellite cells: 2.3 nCPM
  • gastric chief cells: 2.2 nCPM
  • foveolar cells: 1 nCPM
  • kupffer cells: 1 nCPM
  • lacrimal acinar cells: 0.9 nCPM

Immune cell

  • classical monocyte: 25 nTPM
  • myeloid DC: 15 nTPM
  • total PBMC: 7.1 nTPM
  • memory B-cell: 5.8 nTPM
  • naive B-cell: 4.9 nTPM
  • intermediate monocyte: 2.9 nTPM

Brain region

  • choroid plexus: 6.4 nTPM
  • hypothalamus: 5.2 nTPM
  • white matter: 4.7 nTPM
  • medulla oblongata: 4.5 nTPM
  • spinal cord: 4.3 nTPM
  • midbrain: 3.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANG.

Disease | AllUniProt

Conditions ANG is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 121 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Amyotrophic lateral sclerosis type 9

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0.29
gnomAD missense Z
0.08
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANG as an antibody target. Whether an autoantibody or antibody against ANG could matter depends on whether native ANG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANG is annotated as secreted, so native ANG circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ANG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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