Seroatlas · Human Serome Atlas

MREG

Melanoregulin

Also known as: DSU, FLJ10116, MREG_HUMAN, WDT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N565
Gene: MREG
Ensembl: ENSG00000118242
Chromosome: 2
Canonical length: 214 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in melanocyte differentiation; melanosome transport; and phagosome maturation. Predicted to act upstream of or within developmental pigmentation. Predicted to be located in late endosome membrane and melanosome membrane. Predicted to be part of protein-containing complex. Predicted to be active in melanosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q8N565|MREG
     1  MGLRDWLRTV CCCCGCECLE ERALPEKEPL VSDNNPYSSF GATLVRDDEK NLWSMPHDVS
    61  HTEADDDRTL YNLIVIRNQQ AKDSEEWQKL NYDIHTLRQV RREVRNRWKC ILEDLGFQKE
   121  ADSLLSVTKL STISDSKNTR KAREMLLKLA EETNIFPTSW ELSERYLFVV DRLIALDAAE
   181  EFFKLARRTY PKKPGVPCLA DGQKELHYLP FPSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MREG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

retina: 43 nTPM
esophagus: 27 nTPM
cerebellum: 25 nTPM
breast: 20 nTPM
skin: 19 nTPM
liver: 17 nTPM

Single-cell type

esophageal apical cells: 293 nCPM
endometrial glandular cells: 183 nCPM
cone photoreceptor cells: 141 nCPM
adipocytes: 141 nCPM
esophageal suprabasal cells: 125 nCPM
endometrial secretory cells: 102 nCPM

Immune cell

plasmacytoid DC: 2.1 nTPM
basophil: 1.5 nTPM
MAIT T-cell: 1.2 nTPM
memory B-cell: 1.1 nTPM
memory CD8 T-cell: 1 nTPM
T-reg: 1 nTPM

Brain region

cerebellum: 41 nTPM
cerebral cortex: 22 nTPM
thalamus: 17 nTPM
choroid plexus: 17 nTPM
pons: 16 nTPM
white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Melanoregulin
Melanoregulin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MREG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MREG as an antibody target. Whether an autoantibody or antibody against MREG could matter depends on whether native MREG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MREG is annotated at the cell surface, where native MREG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MREG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...