Seroatlas · Human Serome Atlas

ARHGAP30

Rho GTPase-activating protein 30

Also known as: FLJ00267, RHG30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6I6
Gene: ARHGAP30
Ensembl: ENSG00000186517
Chromosome: 1
Canonical length: 1101 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables GTPase activator activity. Involved in negative regulation of Rho protein signal transduction. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1101 residues, UniProt reviewed canonical sequence.

>Q7Z6I6|ARHGAP30
     1  MKSRQKGKKK GSAKERVFGC DLQEHLQHSG QEVPQVLKSC AEFVEEYGVV DGIYRLSGVS
    61  SNIQKLRQEF ESERKPDLRR DVYLQDIHCV SSLCKAYFRE LPDPLLTYRL YDKFAEAVGV
   121  QLEPERLVKI LEVLRELPVP NYRTLEFLMR HLVHMASFSA QTNMHARNLA IVWAPNLLRS
   181  KDIEASGFNG TAAFMEVRVQ SIVVEFILTH VDQLFGGAAL SGGEVESGWR SLPGTRASGS
   241  PEDLMPRPLP YHLPSILQAG DGPPQMRPYH TIIEIAEHKR KGSLKVRKWR SIFNLGRSGH
   301  ETKRKLPRGA EDREDKSNKG TLRPAKSMDS LSAAAGASDE PEGLVGPSSP RPSPLLPESL
   361  ENDSIEAAEG EQEPEAEALG GTNSEPGTPR AGRSAIRAGG SSRAERCAGV HISDPYNVNL
   421  PLHITSILSV PPNIISNVSL ARLTRGLECP ALQHRPSPAS GPGPGPGLGP GPPDEKLEAS
   481  PASSPLADSG PDDLAPALED SLSQEVQDSF SFLEDSSSSE PEWVGAEDGE VAQAEAAGAA
   541  FSPGEDDPGM GYLEELLGVG PQVEEFSVEP PLDDLSLDEA QFVLAPSCCS LDSAGPRPEV
   601  EEENGEEVFL SAYDDLSPLL GPKPPIWKGS GSLEGEAAGC GRQALGQGGE EQACWEVGED
   661  KQAEPGGRLD IREEAEGSPE TKVEAGKASE DRGEAGGSQE TKVRLREGSR EETEAKEEKS
   721  KGQKKADSME AKGVEEPGGD EYTDEKEKEI EREEDEQREE AQVEAGRDLE QGAQEDQVAE
   781  EKWEVVQKQE AEGVREDEDK GQREKGYHEA RKDQGDGEDS RSPEAATEGG AGEVSKERES
   841  GDGEAEGDQR AGGYYLEEDT LSEGSGVASL EVDCAKEGNP HSSEMEEVAP QPPQPEEMEP
   901  EGQPSPDGCL CPCSLGLGGV GMRLASTLVQ VQQVRSVPVV PPKPQFAKMP SAMCSKIHVA
   961  PANPCPRPGR LDGTPGERAW GSRASRSSWR NGGSLSFDAA VALARDRQRT EAQGVRRTQT
  1021  CTEGGDYCLI PRTSPCSMIS AHSPRPLSCL ELPSEGAEGS GSRSRLSLPP REPQVPDPLL
  1081  SSQRRSYAFE TQANPGKGEG L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

spleen: 73 nTPM
lymph node: 72 nTPM
thymus: 59 nTPM
tonsil: 57 nTPM
bone marrow: 54 nTPM
appendix: 53 nTPM

Single-cell type

neutrophils: 462 nCPM
neutrophil progenitors: 246 nCPM
monocytes: 141 nCPM
nk-cells: 130 nCPM
monocyte progenitors: 127 nCPM
t-cells: 104 nCPM

Immune cell

neutrophil: 49 nTPM
non-classical monocyte: 47 nTPM
total PBMC: 33 nTPM
eosinophil: 33 nTPM
gdT-cell: 33 nTPM
intermediate monocyte: 32 nTPM

Brain region

white matter: 12 nTPM
thalamus: 12 nTPM
medulla oblongata: 11 nTPM
pons: 9.2 nTPM
spinal cord: 8.9 nTPM
cerebral cortex: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: -0.1
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RHOU

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP30 as an antibody target. Whether an autoantibody or antibody against ARHGAP30 could matter depends on whether native ARHGAP30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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