Seroatlas · Human Serome Atlas

TCEA2

Transcription elongation factor A protein 2

Also known as: TCEA2_HUMAN, TFIIS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15560
Gene: TCEA2
Ensembl: ENSG00000171703
Chromosome: 20
Canonical length: 299 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Basal body

OverviewNCBI Gene

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q15560|TCEA2
     1  MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG MSVNALRKQS
    61  SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS RDASEAPDPS RKRPELPRAP
   121  STPRITTFPP VPVTCDAVRN KCREMLTAAL QTDHDHVAIG ADCERLSAQI EECIFRDVGN
   181  TDMKYKNRVR SRISNLKDAK NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK
   241  EAIREHQMAR TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 121 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 121 nTPM
cerebellum: 111 nTPM
basal ganglia: 108 nTPM
amygdala: 105 nTPM
hypothalamus: 99 nTPM
hippocampal formation: 94 nTPM

Single-cell type

late spermatids: 260 nCPM
megakaryocytes: 198 nCPM
late primary spermatocytes: 189 nCPM
early spermatids: 105 nCPM
fallopian tube ciliated cells: 92 nCPM
epididymal principal cells: 82 nCPM

Immune cell

memory B-cell: 7.5 nTPM
T-reg: 3.9 nTPM
naive CD4 T-cell: 3.3 nTPM
eosinophil: 3.2 nTPM
naive B-cell: 2.8 nTPM
NK-cell: 2.6 nTPM

Brain region

cerebral cortex: 120 nTPM
pons: 113 nTPM
medulla oblongata: 99 nTPM
amygdala: 96 nTPM
midbrain: 95 nTPM
thalamus: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCEA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEA2 as an antibody target. Whether an autoantibody or antibody against TCEA2 could matter depends on whether native TCEA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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