Seroatlas · Human Serome Atlas

RINL

Ras and Rab interactor-like protein

Also known as: FLJ45909, RINL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZS11
Gene: RINL
Ensembl: ENSG00000187994
Chromosome: 19
Canonical length: 566 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endocytosis. Predicted to be located in ruffle. Predicted to be active in cytosol and endocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>Q6ZS11|RINL
     1  MAQPEDKAPE VPTEGVRLVP PQVNKADRTP LGVLSTLEPL TRLQRTWGVW HVPELDTQDA
    61  EALVGLWPLG SFLVTGRDPS QALVLRSGPL PGEVNTYQIQ KIPRGVSLES SNLCMPDLPH
   121  LLAFLSASRD VLPRTLLLPP PTLGPRDEHT DPVQIGRVQQ DTPGKVLSIV NQLYLETHRG
   181  WGREQTPQET EPEAAQRHDP APRNPAPHGV SWVKGPLSPE VDHPGPALAS LLEEEEEDLE
   241  GKEEGREDDP EEEGPEDVLT IHVQSLVRAR SSYVARQYRS LRVRIASDSG GPHGSGDPAT
   301  ELLQDVRHLL TDLQDHLAKD SYIRAVFGSR GPGLPKKDED PGPALETAVC QAVLAPLKPA
   361  LWTRLRTLRA PELRRLRRRQ TALRAGAGPP GAQGPGPEGQ SPAPALRSRI HERLAHLHAA
   421  CAPRRKVALL LEVCRDVYAG LARGENQDPL GADAFLPALT EELIWSPDIG DTQLDVEFLM
   481  ELLDPDELRG EAGYYLTTWF GALHHIAHYQ PETDRAPRGL SSEARASLHQ WHRRRTLHRK
   541  DHPRAQANLP FKEPWAEETV TGTSDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RINL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

spleen: 13 nTPM
pancreas: 12 nTPM
basal ganglia: 9.9 nTPM
lymph node: 9 nTPM
cerebral cortex: 7.1 nTPM
tonsil: 7.1 nTPM

Single-cell type

nk-cells: 12 nCPM
t-cells: 7.9 nCPM
lymphatic endothelial cells: 7 nCPM
myosatellite cells: 6.9 nCPM
microglia: 6.7 nCPM
cytotrophoblasts: 6.1 nCPM

Immune cell

naive B-cell: 22 nTPM
memory B-cell: 18 nTPM
plasmacytoid DC: 16 nTPM
gdT-cell: 10 nTPM
T-reg: 8.1 nTPM
memory CD8 T-cell: 7.7 nTPM

Brain region

pons: 6.2 nTPM
choroid plexus: 6.1 nTPM
basal ganglia: 5.7 nTPM
cerebellum: 5.5 nTPM
cerebral cortex: 5.2 nTPM
hypothalamus: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 1.23
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RINL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RINL as an antibody target. Whether an autoantibody or antibody against RINL could matter depends on whether native RINL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RINL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RINL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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