Seroatlas · Human Serome Atlas

R3HDM2

R3H domain-containing protein 2

Also known as: KIAA1002, R3HD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2K5
Gene: R3HDM2
Ensembl: ENSG00000179912
Chromosome: 12
Canonical length: 976 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

976 residues, UniProt reviewed canonical sequence.

>Q9Y2K5|R3HDM2
     1  MSNSNTTQET LEIMKESEKK LVEESVNKNK FISKTPSKEE IEKECEDTSL RQETQRRTSN
    61  HGHARKRAKS NSKLKLVRSL AVCEESSTPF ADGPLETQDI IQLHISCPSD KEEEKSTKDV
   121  SEKEDKDKNK EKIPRKMLSR DSSQEYTDST GIDLHEFLVN TLKKNPRDRM MLLKLEQEIL
   181  EFINDNNNQF KKFPQMTSYH RMLLHRVAAY FGMDHNVDQT GKAVIINKTS NTRIPEQRFS
   241  EHIKDEKNTE FQQRFILKRD DASMDRDDNQ TGQNGYLNDI RLSKEAFSSS SHKRRQIFRG
   301  NREGLSRTSS SRQSSTDSEL KSLEPRPWSS TDSDGSVRSM RPPVTKASSF SGISILTRGD
   361  SIGSSKGGSA GRISRPGMAL GAPEVCNQVT SSQSVRGLLP CTAQQQQQQQ QQQLPALPPT
   421  PQQQPPLNNH MISQADDLSN PFGQMSLSRQ GSTEAADPSA ALFQTPLISQ HPQQTSFIMA
   481  STGQPLPTSN YSTSSHAPPT QQVLPPQGYM QPPQQIQVSY YPPGQYPNSN QQYRPLSHPV
   541  AYSPQRGQQL PQPSQQPGLQ PMMPNQQQAA YQGMIGVQQP QNQGLLSSQR SSMGGQMQGL
   601  VVQYTPLPSY QVPVGSDSQN VVQPPFQQPM LVPVSQSVQG GLPAAGVPVY YSMIPPAQQN
   661  GTSPSVGFLQ PPGSEQYQMP QSPSPCSPPQ MPQQYSGVSP SGPGVVVMQL NVPNGPQPPQ
   721  NPSMVQWSHC KYYSMDQRGQ KPGDLYSPDS SPQANTQMSS SPVTSPTQSP APSPVTSLSS
   781  VCTGLSPLPV LTQFPRPGGP AQGDGRYSLL GQPLQYNLSI CPPLLHGQST YTVHQGQSGL
   841  KHGNRGKRQA LKSASTDLGT ADVVLGRVLE VTDLPEGITR TEADKLFTQL AMSGAKIQWL
   901  KDAQGLPGGG GGDNSGTAEN GRHSDLAALY TIVAVFPSPL AAQNASLRLN NSVSRFKLRM
   961  AKKNYDLRIL ERASSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against R3HDM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 40 nTPM
cerebellum: 36 nTPM
retina: 32 nTPM
heart muscle: 32 nTPM
cerebral cortex: 31 nTPM
ovary: 28 nTPM

Single-cell type

myonuclei: 745 nCPM
lactotrophs: 476 nCPM
neutrophils: 449 nCPM
sertoli cells: 422 nCPM
neutrophil progenitors: 348 nCPM
brain excitatory neurons: 330 nCPM

Immune cell

non-classical monocyte: 5.8 nTPM
neutrophil: 4.9 nTPM
basophil: 4.7 nTPM
memory B-cell: 4.7 nTPM
NK-cell: 3.2 nTPM
naive CD4 T-cell: 3 nTPM

Brain region

cerebral cortex: 104 nTPM
white matter: 87 nTPM
cerebellum: 74 nTPM
amygdala: 71 nTPM
basal ganglia: 69 nTPM
thalamus: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 3.33
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of R3HDM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads R3HDM2 as an antibody target. Whether an autoantibody or antibody against R3HDM2 could matter depends on whether native R3HDM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

R3HDM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label R3HDM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...