Seroatlas · Human Serome Atlas

IER3

Radiation-inducible immediate-early gene IEX-1

Also known as: DIF-2, IEX-1, IEX-1L, IEX1_HUMAN, PRG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46695
Gene: IER3
Ensembl: ENSG00000137331
Chromosome: 6
Canonical length: 156 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>P46695|IER3
     1  MCHSRSCHPT MTILQAPTPA PSTIPGPRRG SGPEIFTFDP LPEPAAAPAG RPSASRGHRK
    61  RSRRVLYPRV VRRQLPVEEP NPAKRLLFLL LTIVFCQILM AEEGVPAPLP PEDAPNAASL
   121  APTPVSAVLE PFNLTSEPSD YALDLSTFLQ QHPAAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IER3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 253 nTPM

Expression across tissuesHPA

Tissue

esophagus: 253 nTPM
vagina: 192 nTPM
kidney: 189 nTPM
heart muscle: 163 nTPM
lung: 161 nTPM
stomach: 153 nTPM

Single-cell type

endometrial glandular cells: 178 nCPM
neutrophils: 133 nCPM
endometrial secretory cells: 128 nCPM
epididymal basal cells: 102 nCPM
endometrial luminal cells: 94 nCPM
renal connecting tubule cells: 88 nCPM

Immune cell

basophil: 0.3 nTPM
T-reg: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 0.3 nTPM
medulla oblongata: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM
midbrain: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.63
gnomAD missense Z: 1.23
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Radiation-inducible immediate-early gene IEX-1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IER3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP2R5B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IER3 as an antibody target. Whether an autoantibody or antibody against IER3 could matter depends on whether native IER3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IER3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IER3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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