POU2F3

Protein identityUniProt · HPA

UniProt accession

Q9UKI9

Gene

POU2F3

Ensembl

ENSG00000137709

Chromosome

11

Canonical length

436 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q9UKI9|POU2F3
     1  MVNLESMHTD IKMSGDVADS TDARSTLSQV EPGNDRNGLD FNRQIKTEDL SDSLQQTLSH
    61  RPCHLSQGPA MMSGNQMSGL NASPCQDMAS LHPLQQLVLV PGHLQSVSQF LLSQTQPGQQ
   121  GLQPNLLPFP QQQSGLLLPQ TGPGLASQAF GHPGLPGSSL EPHLEASQHL PVPKHLPSSG
   181  GADEPSDLEE LEKFAKTFKQ RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS RFEALNLSFK
   241  NMCKLKPLLE KWLNDAESSP SDPSVSTPSS YPSLSEVFGR KRKKRTSIET NIRLTLEKRF
   301  QDNPKPSSEE ISMIAEQLSM EKEVVRVWFC NRRQKEKRIN CPVATPIKPP VYNSRLVSPS
   361  GSLGPLSVPP VHSTMPGTVT SSCSPGNNSR PSSPGSGLHA SSPTASQNNS KAAVNSASSF
   421  NSSGSWYRWN HSTYLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POU2F3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

45 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POU2F3.

Disease | AutoantibodyPubMed

Conditions in which antibodies against POU2F3 are reported. Each links to that disease's full target list.

• Thrombocytopenia 4

ReferencesPubMed · IEDB

Publications for POU2F3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.83

gnomAD pLI

0

gnomAD missense Z

0.32

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• epidermis development
• host-mediated suppression of viral transcription
• keratinocyte differentiation
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II
• wound healing

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• identical protein binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytosol
• nuclear body
• nucleolus
• nucleoplasm
• nucleus
• plasma membrane
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• POU-specific domain
• Octamer-binding transcription factor
• Homeodomain
• Homedomain-like superfamily
• Lambda repressor-like, DNA-binding domain superfamily
• POU domain
• Homeobox, conserved site
• POU domain transcription factor
• Homeodomain
• Pou domain - N-terminal to homeobox domain

KeywordsUniProt

• DNA-binding
• Homeobox
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of POU2F3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• POU2AF2
• POU2AF3