Seroatlas · Human Serome Atlas

POU2AF3

POU class 2 homeobox associating factor 3

Also known as: C11orf93, CASC13, COLCA2, OCA-T2, OCAT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8K830
Gene: POU2AF3
Ensembl: ENSG00000214290
Chromosome: 11
Canonical length: 251 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>A8K830|POU2AF3
     1  MSEKPKVYQG VRVKITVKEL LQQRRAHQAA SGGTRSGGSS VHLSDPVAPS SAGLYFEPEP
    61  ISSTPNYLQR GEFSSCVSCE ENSSCLDQIF DSYLQTEMHP EPLLNSTQSA PHHFPDSFQA
   121  TPFCFNQSLI PGSPSNSSIL SGSLDYSYSP VQLPSYAPEN YNSPASLDTR TCGYPPEDHS
   181  YQHLSSHAQY SCFSSATTSI CYCASCEAED LDALQAAEYF YPSTDCVDFA PSAAATSDFY
   241  KRETNCDICY S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POU2AF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

epididymis: 21 nTPM
stomach: 19 nTPM
salivary gland: 16 nTPM
fallopian tube: 15 nTPM
parathyroid gland: 14 nTPM
seminal vesicle: 13 nTPM

Single-cell type

early spermatids: 112 nCPM
late spermatids: 95 nCPM
respiratory ciliated cells: 39 nCPM
fallopian tube ciliated cells: 32 nCPM
cholangiocytes: 31 nCPM
basal prostatic cells: 30 nCPM

Immune cell

memory B-cell: 0.4 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 14 nTPM
basal ganglia: 9.9 nTPM
thalamus: 9.6 nTPM
medulla oblongata: 8.8 nTPM
hippocampal formation: 8.7 nTPM
cerebral cortex: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.75
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

OCA domain
POU class 2 homeobox associating factor 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POU2AF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

POU2F3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POU2AF3 as an antibody target. Whether an autoantibody or antibody against POU2AF3 could matter depends on whether native POU2AF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POU2AF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POU2AF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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