Seroatlas · Human Serome Atlas

POU2AF2

POU domain class 2-associating factor 2

Also known as: C11orf53, MGC50104, OCA-T1, OCAT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXP5
Gene: POU2AF2
Ensembl: ENSG00000150750
Chromosome: 11
Canonical length: 288 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables sequence-specific DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q8IXP5|POU2AF2
     1  MESVPGDYSK RVYQGVRVKH TVKDLLAEKR SGQTSNSRLN GSVSSSQSPF VQMPGSPVTS
    61  GYYGVRRSFL SDSDFHNSKQ FSNDVYTSSV GKPFPCESSA GQSHAALLEP YFPQEPYGDY
   121  RPPALTPNAG SLFSASPLPP LLPPPFPGDP AHFLFRDSWE QTLPDGLSQP DPVSADALLT
   181  LPPSTSCLSQ LESGSIAQHR GSSWGSSLAG AQSYSLHALE DLHHTPGYPT PPPYPFTPFM
   241  TVSNDLPPKV GPLSPDEEAD TGSLHDPSPW VKEDGSIAWG SYECRRAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POU2AF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

testis: 4.9 nTPM
stomach: 2.9 nTPM
breast: 2.4 nTPM
salivary gland: 2 nTPM
skeletal muscle: 1.7 nTPM
colon: 1.3 nTPM

Single-cell type

tuft cells: 219 nCPM
late primary spermatocytes: 60 nCPM
early spermatids: 14 nCPM
cholangiocytes: 14 nCPM
epididymal clear cells: 12 nCPM
late spermatids: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

OCA domain
POU domain class 2-associating factor 2
POU domain class 2-associating factor 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POU2AF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

POU2F3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POU2AF2 as an antibody target. Whether an autoantibody or antibody against POU2AF2 could matter depends on whether native POU2AF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POU2AF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POU2AF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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