Seroatlas · Human Serome Atlas

PAXX

Protein PAXX

Also known as: C9orf142, PAXX_HUMAN, XLS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUH6
Gene: PAXX
Ensembl: ENSG00000148362
Chromosome: 9
Canonical length: 204 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene plays a role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair. The encoded protein may function to stabilize the Ku70/Ku80 heterodimer to facilitate the assembly and maintain the stability of the NHEJ complex. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q9BUH6|PAXX
     1  MDPLSPPLCT LPPGPEPPRF VCYCEGEESG EGDRGGFNLY VTDAAELWST CFTPDSLAAL
    61  KARFGLSAAE DITPRFRAAC EQQAVALTLQ EDRASLTLSG GPSALAFDLS KVPGPEAAPR
   121  LRALTLGLAK RVWSLERRLA AAEETAVSPR KSPRPAGPQL FLPDPDPQRG GPGPGVRRRC
   181  PGESLINPGF KSKKPAGGVD FDET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAXX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 67 nTPM
midbrain: 54 nTPM
amygdala: 50 nTPM
hippocampal formation: 48 nTPM
basal ganglia: 45 nTPM
spleen: 45 nTPM

Single-cell type

pdcs: 272 nCPM
extravillous trophoblasts: 246 nCPM
migrating cytotrophoblasts: 204 nCPM
cytotrophoblasts: 173 nCPM
nk-cells: 146 nCPM
esophageal basal cells: 127 nCPM

Immune cell

plasmacytoid DC: 239 nTPM
gdT-cell: 143 nTPM
memory CD8 T-cell: 124 nTPM
MAIT T-cell: 123 nTPM
naive CD8 T-cell: 99 nTPM
NK-cell: 88 nTPM

Brain region

medulla oblongata: 46 nTPM
white matter: 44 nTPM
spinal cord: 41 nTPM
midbrain: 40 nTPM
cerebellum: 38 nTPM
pons: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0.01
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein PAXX
Protein PAXX, N-terminal domain
PAXX, PAralog of XRCC4 and XLF, also called C9orf142

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAXX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

POLL

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAXX as an antibody target. Whether an autoantibody or antibody against PAXX could matter depends on whether native PAXX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAXX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAXX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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