Seroatlas · Human Serome Atlas

LDLRAD1

Low-density lipoprotein receptor class A domain-containing protein 1

Also known as: LRAD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T700
Gene: LDLRAD1
Ensembl: ENSG00000203985
Chromosome: 1
Canonical length: 205 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Primary cilium

OverviewNCBI Gene

Predicted to be involved in vesicle-mediated transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q5T700|LDLRAD1
     1  MNKVFPQGEN GYTAAESKAH PGGEAGGGHL CCSRRGACLS ASLLLLLATV AALIALVTIL
    61  GLPSCTPGAQ ACITLTNRTG FLCHDQRSCI PASGVCDGVR TCTHGEDEDE SLCRDVPQSL
   121  PHFLVAHCGD PASWIYSDQK CDGTNNCGDC SDELSPVTVC PPCGPGWWRC PSTFFKYCDC
   181  IPRHLCRDHV QHCSDWSDEY ACPGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LDLRAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 109 nTPM
lung: 5.3 nTPM
cervix: 4.2 nTPM
salivary gland: 2.6 nTPM
stomach: 1.3 nTPM
adrenal gland: 1.2 nTPM

Single-cell type

fallopian tube ciliated cells: 428 nCPM
respiratory ciliated cells: 371 nCPM
endometrial ciliated cells: 129 nCPM
epididymal efferent duct ciliated cells: 93 nCPM
neuroendocrine cells: 13 nCPM
esophageal apical cells: 9 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 2.9 nTPM
white matter: 2.6 nTPM
choroid plexus: 2.1 nTPM
amygdala: 2 nTPM
cerebral cortex: 2 nTPM
medulla oblongata: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

vesicle-mediated transport

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Low-density lipoprotein (LDL) receptor class A repeat
LDL receptor-like superfamily
Low-density lipoprotein receptor
Low-density lipoprotein receptor domain class A
LDLRAD1-like, C-terminal domain
LDLRAD1-like, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LDLRAD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LDLRAD1 as an antibody target. Whether an autoantibody or antibody against LDLRAD1 could matter depends on whether native LDLRAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LDLRAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LDLRAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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