Seroatlas · Human Serome Atlas

PHETA2

Sesquipedalian-2

Also known as: DKFZp686J07229, FAM109B, IPIP27B, SES2, SESQ2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ICB4
Gene: PHETA2
Ensembl: ENSG00000177096
Chromosome: 22
Canonical length: 259 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein homodimerization activity. Involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Located in cytoplasmic vesicle and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q6ICB4|PHETA2
     1  MKLNERSVAH YALSDSPADH MGFLRTWGGP GTPPTPSGTG RRCWFVLKGN LLFSFESREG
    61  RAPLSLVVLE GCTVELAEAP VPEEFAFAIC FDAPGVRPHL LAAEGPAAQE AWVKVLSRAS
   121  FGYMRLVVRE LESQLQDARQ SLALQRRSSW KSVASRCKPQ APNHRAAGLE NGHCLSKDSS
   181  PVGLVEEAGS RSAGWGLAEW ELQGPASLLL GKGQSPVSPE TSCFSTLHDW YGQEIVELRQ
   241  CWQKRAQGSH SKCEEQDRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHETA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

pancreas: 18 nTPM
placenta: 15 nTPM
endometrium: 14 nTPM
blood vessel: 13 nTPM
stomach: 13 nTPM
salivary gland: 12 nTPM

Single-cell type

tuft cells: 12 nCPM
platelets: 7 nCPM
pdcs: 3.1 nCPM
microglia: 2.6 nCPM
gastric chief cells: 2.2 nCPM
podocytes: 1.8 nCPM

Immune cell

basophil: 20 nTPM
myeloid DC: 8.4 nTPM
intermediate monocyte: 4.9 nTPM
classical monocyte: 4.3 nTPM
plasmacytoid DC: 3.9 nTPM
total PBMC: 3.2 nTPM

Brain region

choroid plexus: 5.5 nTPM
medulla oblongata: 3 nTPM
spinal cord: 3 nTPM
hypothalamus: 2.5 nTPM
thalamus: 2.4 nTPM
white matter: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein homodimerization activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHETA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHETA2 as an antibody target. Whether an autoantibody or antibody against PHETA2 could matter depends on whether native PHETA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHETA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHETA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...