Seroatlas · Human Serome Atlas

INPP5B

Type II inositol 1,4,5-trisphosphate 5-phosphatase

Also known as: I5P2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32019
Gene
INPP5B
Ensembl
ENSG00000204084
Chromosome
1
Canonical length
993 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Primary cilium tip,Cytosol

OverviewNCBI Gene

This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

993 residues, UniProt reviewed canonical sequence.

>P32019|INPP5B
     1  MDQSVAIQET LAEGEYCVIA VQGVLCEGDS RQSRLLGLVR YRLEHGGQEH ALFLYTHRRM
    61  AITGDDVSLD QIVPVSRDFT LEEVSPDGEL YILGSDVTVQ LDTAELSLVF QLPFGSQTRM
   121  FLHEVARACP GFDSATRDPE FLWLSRYRCA ELELEMPTPR GCNSALVTWP GYATIGGGRY
   181  PSRKKRWGLE EARPQGAGSV LFWGGAMEKT GFRLMERAHG GGFVWGRSAR DGRRDEELEE
   241  AGREMSAAAG SRERNTAGGS NFDGLRPNGK GVPMDQSSRG QDKPESLQPR QNKSKSEITD
   301  MVRSSTITVS DKAHILSMQK FGLRDTIVKS HLLQKEEDYT YIQNFRFFAG TYNVNGQSPK
   361  ECLRLWLSNG IQAPDVYCVG FQELDLSKEA FFFHDTPKEE EWFKAVSEGL HPDAKYAKVK
   421  LIRLVGIMLL LYVKQEHAAY ISEVEAETVG TGIMGRMGNK GGVAIRFQFH NTSICVVNSH
   481  LAAHIEEYER RNQDYKDICS RMQFCQPDPS LPPLTISNHD VILWLGDLNY RIEELDVEKV
   541  KKLIEEKDFQ MLYAYDQLKI QVAAKTVFEG FTEGELTFQP TYKYDTGSDD WDTSEKCRAP
   601  AWCDRILWKG KNITQLSYQS HMALKTSDHK PVSSVFDIGV RVVNDELYRK TLEEIVRSLD
   661  KMENANIPSV SLSKREFCFQ NVKYMQLKVE SFTIHNGQVP CHFEFINKPD EESYCKQWLN
   721  ANPSRGFLLP DSDVEIDLEL FVNKMTATKL NSGEDKIEDI LVLHLDRGKD YFLSVSGNYL
   781  PSCFGSPIHT LCYMREPILD LPLETISELT LMPVWTGDDG SQLDSPMEIP KELWMMVDYL
   841  YRNAVQQEDL FQQPGLRSEF EHIRDCLDTG MIDNLSASNH SVAEALLLFL ESLPEPVICY
   901  STYHNCLECS GNYTASKQVI STLPIFHKNV FHYLMAFLRE LLKNSAKNHL DENILASIFG
   961  SLLLRNPAGH QKLDMTEKKK AQEFIHQFLC NPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INPP5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 21 nTPM
  • ovary: 21 nTPM
  • bone marrow: 19 nTPM
  • tonsil: 18 nTPM
  • cerebellum: 18 nTPM
  • lymph node: 17 nTPM

Single-cell type

  • retinal ganglion cells: 166 nCPM
  • myonuclei: 146 nCPM
  • tuft cells: 127 nCPM
  • retinal horizontal cells: 104 nCPM
  • proximal tubule cells: 104 nCPM
  • distal convoluted tubule cells: 104 nCPM

Immune cell

  • basophil: 27 nTPM
  • eosinophil: 17 nTPM
  • MAIT T-cell: 9.9 nTPM
  • naive B-cell: 7.6 nTPM
  • memory B-cell: 7 nTPM
  • gdT-cell: 6.9 nTPM

Brain region

  • white matter: 32 nTPM
  • cerebellum: 32 nTPM
  • choroid plexus: 26 nTPM
  • medulla oblongata: 26 nTPM
  • pons: 25 nTPM
  • thalamus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INPP5B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 226 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
1.11
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INPP5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INPP5B as an antibody target. Whether an autoantibody or antibody against INPP5B could matter depends on whether native INPP5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INPP5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INPP5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INPP5B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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