Seroatlas · Human Serome Atlas

PHETA1

Sesquipedalian-1

Also known as: FAM109A, FLJ32356, IPIP27A, SES1, SESQ1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4B1
Gene: PHETA1
Ensembl: ENSG00000198324
Chromosome: 12
Canonical length: 249 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q8N4B1|PHETA1
     1  MKLNERSLAF YATCDAPVDN AGFLYKKGGR HAAYHRRWFV LRGNMLFYFE DAASREPVGV
    61  IILEGCTVEL VEAAEEFAFA VRFAGTRART YVLAAESQDA MEGWVKALSR ASFDYLRLVV
   121  RELEQQLAAV RGGGGMALPQ PQPQSLPLPP SLPSALAPVP SLPSAPAPVP ALPLPRRPSA
   181  LPPKENGCAV WSTEATFRPG PEPPPPPPRR RASAPHGPLD MAPFARLHEC YGQEIRALRG
   241  QWLSSRVQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHETA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

small intestine: 23 nTPM
duodenum: 23 nTPM
stomach: 15 nTPM
pancreas: 14 nTPM
spleen: 11 nTPM
liver: 10 nTPM

Single-cell type

early spermatids: 58 nCPM
enterocytes: 56 nCPM
foveolar cells: 44 nCPM
mucous neck cells: 35 nCPM
colonocytes: 26 nCPM
alveolar cells type 1: 25 nCPM

Immune cell

myeloid DC: 3 nTPM
intermediate monocyte: 1.8 nTPM
non-classical monocyte: 1.8 nTPM
classical monocyte: 1.2 nTPM
naive B-cell: 0.9 nTPM
total PBMC: 0.9 nTPM

Brain region

medulla oblongata: 11 nTPM
thalamus: 11 nTPM
hypothalamus: 9.8 nTPM
amygdala: 9.5 nTPM
midbrain: 9.3 nTPM
pons: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.01
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein homodimerization activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHETA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHETA1 as an antibody target. Whether an autoantibody or antibody against PHETA1 could matter depends on whether native PHETA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHETA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHETA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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