Seroatlas · Human Serome Atlas

PLEKHJ1

Pleckstrin homology domain-containing family J member 1

Also known as: FLJ10297, PKHJ1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NW61
Gene: PLEKHJ1
Ensembl: ENSG00000104886
Chromosome: 19
Canonical length: 149 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and cytosol. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q9NW61|PLEKHJ1
     1  MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT DEAEPVGALL
    61  LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM EALRRASYEF MRRSLIFYRN
   121  EIRKVTGKDP LEQFGISEEA RFQLSGLQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHJ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

colon: 103 nTPM
duodenum: 99 nTPM
kidney: 97 nTPM
small intestine: 95 nTPM
stomach: 93 nTPM
pancreas: 90 nTPM

Single-cell type

enterocytes: 319 nCPM
colonocytes: 305 nCPM
enteric transient amplifying cells: 247 nCPM
paneth cells: 213 nCPM
enteric stem cells: 209 nCPM
parietal cells: 202 nCPM

Immune cell

plasmacytoid DC: 159 nTPM
naive B-cell: 144 nTPM
eosinophil: 130 nTPM
memory B-cell: 119 nTPM
T-reg: 113 nTPM
non-classical monocyte: 109 nTPM

Brain region

thalamus: 45 nTPM
pons: 40 nTPM
midbrain: 37 nTPM
amygdala: 36 nTPM
medulla oblongata: 34 nTPM
cerebral cortex: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.07
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of PLEKHJ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHJ1 as an antibody target. Whether an autoantibody or antibody against PLEKHJ1 could matter depends on whether native PLEKHJ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHJ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHJ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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