Seroatlas · Human Serome Atlas

TREM1

Triggering receptor expressed on myeloid cells 1

Also known as: CD354, TREM-1, TREM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NP99
Gene
TREM1
Ensembl
ENSG00000124731
Chromosome
6
Canonical length
234 aa
Protein class
CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus
Secretome location
Secreted to blood
Quaternary structure
Homomultimer

OverviewNCBI Gene

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q9NP99|TREM1
     1  MRKTRLWGLL WMLFVSELRA ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS SQKAWQIIRD
    61  GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM VNLQVEDSGL YQCVIYQPPK
   121  EPHMLFDRIR LVVTKGFSGT PGSNENSTQN VYKIPPTTTK ALCPLYTSPR TVTQAPPKST
   181  ADVSTPDSEI NLTNVTDIIR VPVFNIVILL AGGFLSKSLV FSVLFAVTLR SFVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TREM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
91 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 91 nTPM
  • lung: 62 nTPM
  • appendix: 42 nTPM
  • adipose tissue: 19 nTPM
  • choroid plexus: 12 nTPM
  • urinary bladder: 12 nTPM

Single-cell type

  • neutrophils: 1,521 nCPM
  • monocytes: 187 nCPM
  • macrophages: 54 nCPM
  • neutrophil progenitors: 49 nCPM
  • monocyte progenitors: 45 nCPM
  • late spermatids: 45 nCPM

Immune cell

  • neutrophil: 617 nTPM
  • classical monocyte: 83 nTPM
  • myeloid DC: 33 nTPM
  • total PBMC: 32 nTPM
  • intermediate monocyte: 21 nTPM
  • non-classical monocyte: 10 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • thalamus: 5 nTPM
  • choroid plexus: 3.9 nTPM
  • pons: 3.4 nTPM
  • medulla oblongata: 1.5 nTPM
  • white matter: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0.01
gnomAD missense Z
0.08
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TREM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TREM1 as an antibody target. Whether an autoantibody or antibody against TREM1 could matter depends on whether native TREM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TREM1 is annotated at the cell surface, where native TREM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TREM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TREM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...